Introduction: Pro-inflammatory chemokines and cytokines   such as MCP-1 and IL6 can activate microglial cells that has found in some neuro-inflammatory disorders. Hypoxia activates cerebral endothelial cells to release these pro-inflammatory mediators. We aimed to investigate the anti-hypoxic effects of different doses of some GABAergic agents. Materials and Methods: We randomly divid...

Casey DP, Curry TB, Wilkins BW, Joyner MJ. Nitric oxidemediated vasodilation becomes independent of -adrenergic receptor activation with increased intensity of hypoxic exercise. J Appl Physiol 110: 687– 694, 2011. First published December 30, 2010; doi:10.1152/japplphysiol.00787.2010.—Hypoxic vasodilation in skeletal muscle at rest is known to include -adrenergic receptorstimulated nitric oxide...

This study aimed at developing immunohistochemical assays for different subpopulations of hypoxic cells in tumors. BALB/c-nu/nu mice bearing A-07 or R-18 tumors were given a single dose of 90 mg/kg body weight or three doses (3 h apart) of 30 mg/kg body weight of pimonidazole hydrochloride intravenously. The fraction of pimonidazole-labeled cells was assessed in paraffin-embedded and frozen tum...

PURPOSE To validate the predictive impact of a hypoxia gene expression classifier in identifying patients with head and neck squamous cell carcinoma (HNSCC) having benefit from hypoxic modification of radiotherapy. PATIENTS AND METHODS Gene expressions were quantified from formalin-fixed, paraffin-embedded tumour biopsies of 323 HNSCC patients randomized for placebo or nimorazole in conjuncti...

Potentiation of hypoxic pulmonary vasoconstriction by a low dose of almitrine bismesylate (1 microgram.kg-1.min-1) was evaluated in terms of blood chemical mediator concentrations. Time course changes in the blood concentrations of adrenaline, noradrenaline, serotonin, histamine, thromboxane TXB2 and 6-keto-PGF1 alpha were monitored after administration of almitrine bismesylate for 15 min at 1 ...

The oxygen dependence of hematoporphyrin derivative (HPD)-induced photoinactivation of Chinese hamster V79 cells was examined. Cells were treated with HPD (25 micrograms/ml) for 2 h and subsequently exposed to red light (greater than 590 nm) under either aerated or hypoxic (less than 10 ppm O2) conditions. Hypoxic cells were found to be extremely resistant to the lethal effects of HPD and light...