BACKGROUND Canarium odontophyllum Miq. is a plant species widely known as 'dabai' and can be vastly found in Sarawak. The aim of this study was to assess the cytotoxic and genotoxic effect of extracts from stem bark of C. odontophyllum against HCT 116 human colorectal cancer cell line. METHOD The IC50 values of the aqueous, methanol, and acetone extracts against HCT 116 cells as well as the a...

Growing evidence suggests that the pyrrolizidine alkaloids (PAs)-induced hepatotoxicity is mediated by multiple cell death/defence modalities. However, the detailed mechanisms are still lacking. In this study, the hepatotoxic effects of four PAs including three retronecine-type ones (senecionine, seneciphylline and monocrotaline) and one otonecine-type (clivorine) on the proliferation of Huh-7....

Hydrolases constitute a class of enzymes widely distributed in nature from bacteria to higher eukaryotes. The halotolerance of many enzymes derived from halophilic bacteria can be exploited wherever enzymatic transformations are required to function under physical and chemical conditions, such as in the presence of organic solvents and extremes in temperature and salt content. In recent years, ...

Background: Oxaliplatin (OXA) is a third-generation platinum based chemotherapy used in the treatment of colorectal cancer (CRC). We recently showed by gene set enrichment analysis (GSEA) that subactive doses OXA induce adaptive changes CRC cell lines, with preservation viability (Tosi et al, ASCO Annual Meeting 2022, abstr. #3091). In particular, widespread negative sets involved DNA repair wa...

We present adaptive optics (AO), near-infrared images of the central starburst region of the Local Group dwarf irregular IC 10. The Keck 2 telescope laser guide star facility was used to achieve near diffraction limited performance at H and K ′ with Strehl ratios of 18% and 32%, respectively. The images are centered on the putative Wolf-Rayet (W-R) object [MAC92] 24. Photometry from AO images c...

γδ T cells producing IL-17A (γδTh17 cells) are known to be involved in peritonitis induced by Escherichia coli infection mice. In vivo treatment with Vγ6-specific mAb (1C10-1F7) significantly hampered resolution of E. infection. Thus, Vγ6+γδTh17 mainly contributed protection against use restricted V genes T-cell receptor (TCR) rearrangement and typically classified Vγ1–Vγ7 gene segments used th...