We present new narrow-band imaging and optical spectroscopy of Wolf-Rayet stars in the Local Group dwarf galaxy IC10 (Gemini-N GMOS) and Sculptor group spiral galaxy NGC300 (VLT FORS2). 1. Gemini-N GMOS observations of IC10 IC10 is a moderately reddened dwarf irregular (or blue compact dwarf) at a distance of 0.9Mpc, with a metal content of log(O/H) 8:2 and an unusually high WC/WN ratio of 2, v...

We previously described the isolation of the IC10 retrovirus which transduced the v-Rmil oncogene, a new member of the mil/raf gene family. This virus was generated during serial passaging of Rous-associated virus type 1 (RAV-1) in chicken embryo neuroretina (NR) cells and was selected for its ability to induce proliferation of these nondividing cells. IC10 was isolated after six passages of cu...

IC10 is the nearest starburst galaxy, as revealed both by its Hα surface brightness and the large number of Wolf-Rayet stars (WRs) per unit area. The relative number of known WCto WN-type WRs has been thought to be unusually high (∼ 2), unexpected for IC10’s metallicity. In this Letter we report the first results of a new and deeper survey for WRs in IC10. We sucessfully detected all of the spe...

RNA interference (RNAi) is a major tool for basic and applied investigations. However, obtaining RNAi data that have physiological significance requires investigation of regulations and therapeutic strategies in appropriate in vivo settings. To examine in vivo gene regulation and protein function in the adult neural stem cell (NSC) niche, we optimized a new non-viral vector for delivery of siRN...

Huntington's disease (HD) is a dominantly inherited, progressive neurodegenerative disease caused by an expanded polyglutamine tract in huntingtin protein (Htt). Medium spiny striatal neurons (MSNs) are primarily affected in HD. Mutant huntingtin protein (Htt(exp)) specifically binds to and activates type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1), an intracellular Ca(2+) release chann...

Among the other dwarf galaxies with violent star formation IC10 galaxy stands out for anomalously high number of Wolf-Rayet (WR) stars. For instance, the number of WR-stars in IC10 is 20 times higher than that in LMC and spatial density of WR stars in IC10 reaches 11 WR stars per square kpc (Massey et al., 2002 [8], Massey et al., 2007 [7], Crowther et al., 2003 [4] and references in these pape...

The mineralization of [14C]acetate was studied in bottles with fresh soil and groundwater. Addition of toxicants inhibited the formation of 14CO2 and dose-effect curves were obtained. The acetate mineralization was not inhibited by zinc, cadmium, K2Cr2O7, chloropyrifos, and paraquat in an acid sandy soil at 1000 mg/kg dry soil. The IC10 is the toxicant concentration which inhibits 10% of the in...

We report the results of spectroscopic observations, obtained with the Gemini North Multi-Object Spectrograph, of 9 planetary nebulae (PNe) and 15 H ii regions located in the 5.5×5.5 inner region of the nearby starburst galaxy IC10. Twelve new candidate PNe have been discovered during our pre-imaging phase. Nine of them have been spectroscopically confirmed. The direct availability of the elect...

We report the discovery of the first known symbiotic star in IC10, a starburst galaxy belonging to the Local Group, at a distance of ∼750 kpc. The symbiotic star was identified during a survey of emission-line objects. It shines at V =24.62±0.04, V −RC=2.77±0.05 and RC−IC=2.39±0.02 and suffers from EB−V =0.85±0.05 reddening. The spectrum of the cool component well matches that of solar neighbor...

We investigate the stellar content of the starburst dwarf galaxy IC10 using accurate and deep optical data collected with the Advanced Camera for Surveys and with the Wide Field Planetary Camera 2 on board the Hubble Space Telescope. The comparison between theory and observations indicates a clear change in age distribution when moving from the center toward the external regions. Moreover, empi...