No significant effective therapy has been established for patients with idiopathic male infertility up to now. In order to assess the role of androgens in idiopathic male infertility, testosterone (T) and 5 alpha-dihydrotestosterone (DHT) levels in isolated seminiferous tubules (intratubular levels) were measured by radioimmunoassay (RIA) in 100 patients with idiopathic male infertility. RIA of...

We investigated a group of male patients with idiopathic infertility to determine the presence of genital infection and to identify the pattern of this infection using a specially designed protocol. A prospective study was carried out on 63 patients and 23 controls. We cultured the first voided urine, semen and swabs taken from the anterior urethra of these patients and controls for bacteria, c...

The review published by Kläver and Gromoll is a timely reminder of the everchanging landscape of the clinical andrology laboratory as well as the limitations of current approaches to properly diagnose and treat male infertility.1 In a variety of disciplines, the clinical relevance of epigenetic status is becoming increasingly apparent. In this paper, the authors review the various studies that ...

Cytokines have been important mediators of the immunity and can be involved in numerous processes in the male genital tract including acting as immunomodulatory elements within the male gonad. The aims of this study were: 1) to detect pro- and anti-inflammatory cytokine levels in the control group and subgroups of infertile men; and 2) to set up the practical recommendations concerning determin...

background: the etiologic cause in near one third of male factor infertility is unknown. the percentage of men with idiopathic infertility who have been successfully treated by the empirical therapeutic modalities is not high. objective: the aim of this study was to assay the effect of l-carnitine on sperm parameters in patients who needs intracytoplasmic sperm injection (icsi) as a method for ...

BACKGROUND Idiopathic infertility is a significant number of causes of male infertility. Empirical treatments are used for idiopathic male infertility, and antioxidant supplementation is a kind of management of oxidative stress related infertility. We investigated the antioxidant effects of the modified Ojayeonjonghwan (KH-204) in a rat model of cryptorchidism. METHOD Male rats were divided i...

Human infertility is often classified as idiopathic in both males and females. Meiotic errors may account for at least part of these cases. As the synaptonemal complex (SC, a meiosis-specific protein scaffold) is essential for successful meiosis progression, in this paper, we analyzed the mutations in genes coding for SC components described in infertile patients to assess to what extent altera...

AIM To study the incidence of single nucleotide polymorphisms in ubiquitin-specific protease 26 (USP26) gene and its involvement in idiopathic male infertility in China. METHODS Routine semen analysis was performed. Infertility factors such as immunological, infectious and biochemical disorders were examined to select patients with idiopathic infertility. DNA was isolated from peripheral bloo...

Abstract: Introduction: In present situation infertility is one of the chief problem for reproductive couples due to multiple factors including lifestyle. Infertility thought be caused by both male and female in 27 percent cases, with 15 cases being idiopathic. Assisted technologies are used these overcome problems related infertility, but success rate ART appreciated WHO if it reaches 30%. Abo...