in a prospective clinical trial, the incidence of scrotal tongue in psoriatic patients was studied. one hundred psoriatics and the same number of non-psoriatic individuals were evaluated for the incidence of fissured tongue, age, duration of illness, and clinical types of psoriasis. in this study 49 psoriatic patients (49%) and 28 non-psoriatic persons (28%) had fissured tongue. the most common...

Psoriasis is a chronic inflammatory skin disease with unknown etiology. Infiltration of inflammatory cells as the initial event in the development of new psoriatic plaques together with the defined inflamed areas of such lesions this argues for an immunological disease with a local production of a causal antigen. Pso p27 is a protein expressed in psoriatic plaques and is shown to participate in...

OBJECTIVE To determine the response of stubborn psoriatic plaques to the 308-nm excimer laser. DESIGN Controlled study with a before-after design. SETTING A university-based clinical research center. PATIENTS Adult subjects with recalcitrant plaque psoriasis that have not responded to other therapies for at least 2 months. INTERVENTIONS Selected psoriatic plaques were treated with the 3...

BACKGROUND Paradoxical cases of psoriatic lesions induced or exacerbated by anti-tumor necrosis factor (TNF)-α therapy have been reported more frequently in recent years, but data related to inflammatory bowel disease (IBD) are rare. A systematic literature review was performed to provide information about this adverse effect in patients with IBD who receive anti-TNF therapy. METHODS Publishe...

Ustekinumab is a fully human monoclonal antibody targeting the common p40 subunit shared by interleukin (IL)-12 and IL-23. Ustekinumab prevents the interaction of IL-12 and IL-23 with their cell surface receptors, and thus blocks T helper (Th)-1 IL-12 and Th-17 IL-23 inflammatory pathways. Ustekinumab has been evaluated in the treatment of various chronic immune-mediated diseases including, pso...

In a prospective clinical trial, the incidence of scrotal tongue in psoriatic patients was studied. One hundred psoriatics and the same number of non-psoriatic individuals were evaluated for the incidence of fissured tongue, age, duration of illness, and clinical types of psoriasis. In this study 49 psoriatic patients (49%) and 28 non-psoriatic persons (28%) had fissured tongue. The most c...

BACKGROUND Our objective was to study tongue lesions and their significance in psoriatic patients. METHODS The oral mucosa was examined in 200 psoriatic patients presenting to Razi Hospital in Tehran, Iran, and 200 matched controls. RESULTS Fissured tongue (FT) and benign migratory glossitis (BMG) were the two most frequent findings. FT was seen more frequently in psoriatic patients (n = 66...

For psoriasis, an idiopathic inflammatory disorder of the skin, the microbial biota has not been defined using cultivation-independent methods. We used broad-range 16S rDNA PCR for archaea and bacteria to examine the microbiota of normal and psoriatic skin. From 6 patients, 19 cutaneous samples (13 from diseased skin and 6 from normal skin) were obtained. Extracted DNA was subjected to the broa...

Biologic therapies may cause so-called "paradoxical side-effects," that is, the onset or exacerbation of new symptoms/diseases for which biological treatment should be effective. Among these, psoriatic skin lesions have been described. We report a case series of ten patients with either new onset (seven cases) or worsening (three cases) of psoriasis occurring during a biologic therapy. Six pati...