The meiotic chromosomes of 10 species (Pohlia elongata, Anomobryum cymbifolium, Brachymenium acuminatum, B. ochianum, B. sikkimense, Bryum cellulare, B. pseudotriquetrum, B. apiculatum, B. capillare and B. atrovirense), in four genera of the family Bryaceae of acrocarpous mosses are studied with special emphasis on their evolution, polyploidy and cytological features with reference to interrela...

The ability of propranolol to inhibit the development of polyploidy in aortic vascular smooth muscle cells associated with hypertension was studied in deoxycorticosterone (DOC)-salt treated rats. Six-week treatment with DOC-salt resulted in significant increases in systolic blood pressure, heart weight, and aortic weight in treated animals compared to increases in uninephrectomized controls. Ad...

The anti-tumor potential of oncolytic adenoviruses (CRAds) has been demonstrated in preclinical and clinical studies. While these agents failed to eradicate tumors when used as a monotherapy, they may be more effective if combined with conventional treatments such as radiotherapy or chemotherapy. This study seeks to evaluate the combination of a CRAd bearing a ∆24 deletion in E1A with valproic ...

Breakdown of self-incompatibility occurs repeatedly in flowering plants with important evolutionary consequences. In plant families in which self-incompatibility is mediated by S-RNases, previous evidence suggests that polyploidy may often directly cause self-compatibility through the formation of diploid pollen grains. We use three approaches to examine relationships between self-incompatibili...

Genomic duplication through polyploidy has played a central role in generating the biodiversity of flowering plants. Nonetheless, how polyploidy shapes species interactions or the ecological dynamics of communities remains largely unknown. Here we provide evidence from a 4 year study demonstrating that the evolution of polyploidy has reshaped the interactions between a widespread plant and thre...

PURPOSE AZD1152 is an Aurora B kinase inhibitor currently in clinical trials. As the topoisomerase I poison CPT-11 induces a G(2) arrest, a mechanistic understanding of the cell cycle interactions between these agents may prove critical for combination therapy. METHODS AZD1152 was tested in vitro and in vivo with SN-38 and CPT-11 against HCT-116 cells. Inhibition of clonogenicity, induction o...

This study was aimed to obtain polyploid plants of viola (Viola acuminata Ledebour) using the antimitotic agent colchicine. Experiments consisted in using colchicine on ungerminated seeds. The seeds were plunged into colchicine solutions in concentrations of 0.01, 0.05, 0.10 and 0.20% for 24 and 48 h. Polyploidy levels (diploid, tetraploid and hexaploid) were firstly detected by chromo...

Genome doubling (polyploidy) has been and continues to be a pervasive force in plant evolution. Modern plant genomes harbor evidence of multiple rounds of past polyploidization events, often followed by massive silencing and elimination of duplicated genes. Recent studies have refined our inferences of the number and timing of polyploidy events and the impact of these events on genome structure...