We developed an innovative hybrid sequencing approach, IDP-fusion, to detect fusion genes, determine fusion sites and identify and quantify fusion isoforms. IDP-fusion is the first method to study gene fusion events by integrating Third Generation Sequencing long reads and Second Generation Sequencing short reads. We applied IDP-fusion to PacBio data and Illumina data from the MCF-7 breast canc...

Allocating an IT Innovation budget to technologies in different maturity stages (mature vs. fashionable IT innovations) is a demanding task for companies. Due to the dynamic innovation cycles with new emerging technologies, many IT innovation investment decisions follow a bandwagon behavior or fixed investment strategies. Instead of optimizing the IT innovation budget’s allocation to mature or ...

This paper presents a project memory (PM) based on a decision-making process model and applied on case studies from PSA PEUGEOT CITROËN Automotive Research and Innovation Department. This research work is developed within the framework of knowledge management systems for design projects of innovative products. First, we discuss the links between innovation, decision-making, knowledge in enginee...

The current state-of-the-art algorithm for optimal coalition structure generation is IDP-IP—an algorithm that combines IDP (a dynamic programming algorithm due to Rahwan and Jennings, 2008b) with IP (a tree-search algorithm due to Rahwan et al., 2009). In this paper we analyse IDP-IP, highlight its limitations, and then develop a new approach for combining IDP with IP that overcomes these limit...

The present paper presented a methodology for prioritizing the innovative and entrepreneurial indicators using Multi Criteria Decision Making (MCDM) and Artificial Neural Networks (ANNs), taking into account three individual, organizational and cultural dimensions simultaneously in decision making procedure. This methodology has two main advantages: first, the speed of operation in the accounti...

Abstract Innovation is considered as a critical factor for organizations to create value and ‎sustainable competitive advantage in today's complex and changing environment. ‎Organizations with more innovation, in response to the changing environments and ‎creating development of new capabilities that allows them to achieve better ‎performance will be more successful. The aim of curr...

Deoxyxylulose 5-phosphate synthase (DXS), a thiamine diphosphate (ThDP) dependent enzyme, plays a regulatory role in the methylerythritol 4-phosphate (MEP) pathway. Isopentenyl diphosphate (IDP) and dimethylallyl diphosphate (DMADP), the end products of this pathway, inhibit DXS by competing with ThDP. Feedback inhibition of DXS by IDP and DMADP constitutes a significant metabolic regulation of...

This paper examines the implications for research into the diffusion of innovations (DOI) arising from a growing body of literature in two related fields. The first area concerns the debate on the role of regional and national systems of innovation (NSI) in the innovation process. The second area deals with the argument that enterprises must move from a “closed innovation” to an “open innovatio...

In recent years society as a whole has become more aware and concerned about environmental issues. In light of increasingly stringent legislation and the more critical eyes of external stakeholders, companies have come to realise the heightening need for their actions to be seen as environmentally responsible. The innovation process provides companies with an excellent opportunity to influence ...

Empirical and theoretical analyses of the management of innovation must carefully disentangle its several dimensions: Who finances R&D expenditures? Who has decision rights over the R&D process and property rights over the innovation? Who receives the return streams derived from the innovation? This paper is a first attempt at opening the R&D blackbox. It studies the foundations for co-financin...