We report a case of reversible encephalopathy syndrome in a 16-year-old girl with acute myelogenous leukemia (AML), who is undergoing during consolidation chemotherapy composed of BH-AC (N4-behenoyl-1-beta-D-arabinofuranosyl cytosine) and idarubicin. On the 6th day of chemotherapy, she was in a drowsy state following generalized tonic clonic seizure lasting 20 minutes. MR images revealed extens...

A 61-year-old man who had been diagnosed with prostate cancer 9 years ago and had been treated with pelvic irradiation and intermittent androgen deprivation therapy visited the emergency room because of back pain and weakness in both legs. Spine magnetic resonance imaging showed a lumbar epidural mass and spine metastasis. The whole-body workup revealed multiple metastases to the lymph nodes, b...

The contribution made by streptomycin (SM) towards the success of antituberculous chemotherapy is by now well established. It is not an “all safe, all powerful” drug, as its use can lead to serious consequences. There appears to be some danger from toxicity of the drug itself, but in our experience this has been relatively low. However, the dosage of streptomycin when used intermittently (two o...

Cancer survival continues to improve, and thus cardiovascular consequences of chemotherapy are increasingly important determinants of long-term morbidity and mortality. Conventional strategies to protect the heart from chemotherapy have important hemodynamic or myelosuppressive side effects. Remote ischemic conditioning (RIC) using intermittent limb ischemia-reperfusion reduces myocardial injur...

Background  Treating tuberculosis (TB) with short-course chemotherapy is recommended by the World Health Organization tuberculosis program and is one of the five packages of directly observed treatment short-course (DOTS) strategy. Objectives  To investigate the effectiveness of short-course chemotherapy for treating new and retreatment TB patients and to assess the impact of drug resistance on...

Background: The impact of continuous and intermittent training on diabetes mellitus condition and its mechanism is not well understood. The aim of the present study was to assess the changes in glucose uptake after 6 weeks of continuous and intermittent exercise training protocols in healthy and streptozotocin (STZ)-induced diabetic rats. Method: Sixty male al...

BACKGROUND Despite their broadly recommended use as chemotherapeutic agents, the porphyrogenicity of methotrexate and actinomycin D have not been confirmed. Accordingly, it is not known whether these agents are safe for use in patients with porphyria. CASE PRESENTATION In this report, we present a case of an invasive mole with lung metastasis in a 49-year-old Japanese woman who had previously...