Objective : An attempt was made to compare the detection of cervical abnormalities between the use of a cotton swab and a Cervex brush in mass cancer screening. Study Design : Of 15,664 women who participated in a cervical cancer screening program in 2002, 8,366 women underwent Cervex brush sampling and 7,298 underwent cotton swab screening to compare the detectability of dysplasia and cancer i...

The etiology and pathogenesis of human transitional cell carcinoma (TCC) remain unknown at the present time. While many carcinogens can induce bladder carcinoma in animal experimental studies, the only well-established carcinogens in human beings are tobacco smoke and arylamines.[1] Experimental studies in animals have demonstrated that invasive urothelial carcinoma is preceded by a sequence of...

Eighteen women with high-grade cervical or vulvar intraepithelial neoplasia who were positive for human papillomavirus (HPV) 16 and were HLA-A2 positive were treated with escalating doses of a vaccine consisting of a 9-amino acid peptide from amino acids 12-20 encoded by the E7 gene emulsified with incomplete Freund's adjuvant. Starting with the eleventh patient, an 8-amino acid peptide 86-93 l...

INTRODUCTION Patients with ulcerative colitis (UC) have a greater risk of developing colorectal cancer (CRC) when compared to the general population. Epithelial dysplasia comes before this neoplasm, and thus endoscopic surveillance is recommended to these patients. This pilot study aims at establishing the incidence of dysplasia and CRC in patients with long-standing UC in our hospital. MATER...

A nested multiplex PCR (NMPCR) assay that combines degenerate E6/E7 consensus primers and type-specific primers was evaluated for the detection and typing of human papillomavirus (HPV) genotypes 6/11, 16, 18, 31, 33, 35, 39, 42, 43, 44, 45, 51, 52, 56, 58, 59, 66, and 68 using HPV DNA-containing plasmids and cervical scrapes (n = 1,525). The performance of the NMPCR assay relative to that of co...

Copyright © 2012. Korean Society of Obstetrics and Gynecology Bacterial vaginosis (BV) is common, treatable condition, where the normal Döderlein-dominated vaginal flora is replaced by other, predominantly anaerobic flora. Previous studies which have examined the relationship between BV and cervical intraepithelial neoplasia (CIN) gave conflicting conclusions with different results which ranged...

OBJECTIVES To evaluate the benefit of using autofluorescence bronchoscopy (AFB) for the detection and localization of early invasive lung cancer. METHODS AFB and white light bronchoscopy (WLB) were performed on 198 cases of suspected lung cancer, and the relative sensitivity of WLB plus AFB compared with WLB alone. RESULTS Included 198 biopsy specimens, and 160 were classified as positive b...

1. Cash R, Wikler D, Saxena A, Capron A, editors. Casebook on ethical issues in international health research. Geneva: World Health Organisation 2009;124-5. 2 Richart RM. Natural history of cervical intraepithelial neoplasia. Clin Obstet Gynecol. 1968:10:748-84. 3. Coppleson M. The value of colposcopy in the detection of preclinical carcinoma of the cervix (Three years’ experience at King Georg...

Objective. To determine the frequency of high risk (HR) HPV and intraepithelial neoplasia following ASCUS pap cytology screens in menopausal women. Study Design. Following IRB approval, we performed a retrospective review of all cases of ASCUS pap tests, HPV results, and relevant clinical-pathologic data in women age 50 or over from November 2005 to January 2007 within a tertiary care center. S...