Curcumin (CUR), a naturally bioactive component in the Curcuma longa have a wide range of biological and pharmacological actions. However, the poor water solubility with poor bioavailability limits its application. The aim of this study was to develop a novel CUR intravenous injection to improve CUR absorption and enhance drug therapy effect. The physical characteristics of CUR intravenous inje...

AIMS We examined the mechanism of action of naftopidil, an α1D/A blocker, on spinal descending serotonergic neurotransmission for the micturition reflex. METHODS We examined (1) urinary 5-hydroxyindole acetic acid (5-HIAA) after intraperitoneal administration of saline, para-chlorophenylalanine (PCPA; a serotonin synthetic enzyme inhibitor), and/or 5-hydroxytryptophan (5-HTP; a serotonin prec...

Staphylococcus aureus is the most common cause of endocarditis in intravenous drug users. The organism gains access by intravenous injection or from the direct invasion of skin at injection sites. Known for its aggressiveness, the right sided endocarditis that ensues can lead to complications such as pulmonary abscesses and even death. We report the unusual case of an intravenous drug abuser, w...

BACKGROUND AND PURPOSE Stroke following the intravenous injection of drugs may be secondary to the direct effect of the substance itself or from embolization by the inert vehicle used in the manufacturing process of the drug. CASE DESCRIPTION We describe a 39-year-old man who developed a left homonymous hemianopia after intravenous injection of a melted suppository. CONCLUSIONS Paradoxical ...

In the article “The history of peripheral intravenous catheters” in ACTA ANAESTHESIOL. BELG. 56, 271-82, 2005 (1), it is stated that the first serious attempts of intravenous administration of drugs were made in 1658 by Sir Christopher Wren (16321723). This date is contradictory to common historical knowledge which dates Wrens experiments back to the year 1656 and give reason to celebrate the 3...

A 38-year-old woman presented to our pulmonology clinic with complaints of progressive dyspnea and dry cough for more than three months. She denied fever or weight loss. On physical examination, she presented as hypoxemic, with a room air oxygen saturation of 92% and an RR of 24 breaths/min. Pulmonary function tests showed that spirometric values were within normal limits, but there was a sligh...

WARNING Serious and fatal blood dyscrasias (aplastic anemia, hypoplastic anemia, thrombocytopenia and granulocytopenia) are known to occur after the administration of chloramphenicol. In addition, there have been reports of aplastic anemia attributed to chloramphenicol which later terminated in leukemia. Blood dyscrasias have occurred after both short term and prolonged therapy with this drug. ...

A great drawback to guinea pigs as experimental material lies in the difficulty of intravascular injections. Direct cardiac puncture is, of course, readily performed, but much of an injected fluid may escape into the pericardial sac, or the pleural cavity, and the operator be none the wiser. Dosage is well controlled when the jugular vein is used, but this must be bared by incision, and day to ...