Hayashi1) reported that a convulsive seizure can be induced on dogs, by injecting a very minute amount of sodium salt of glutamic acid into the cortex of the brain. We also observed a similar phenomenon caused by injecting the drug into the brain or the spinal cord of a frog or a toad. The present experiment was undertaken in order to investigate the effect of glutamic acid upon the potentials ...

Magnetic resonance and relative enzymatic velocity studies with the use of the paramagnetic manganese ion were carried out on creatine kinase inactivated by the specific -SH reagents iodoacetic acid and dinitrofluorobenzene and by the nonspecific reagents urea and decyl sulfate. Modification of creatine kinase at the two essential --SH groups by iodoacetic acid or dinitrofluorobenzene affected ...

PURPOSE. Transgenic pigs carrying a mutant human rhodopsin transgene have been developed as a large animal model of retinitis pigmentosa (RP). This model displays some key features of human RP, but the time course of disease progression makes this model costly, time consuming, and difficult to study because of the size of the animals at end-stage disease. Here, the authors evaluate an iodoaceti...

In helically-cut strips of cerebral arteries isolated from dogs and monkeys, the addition of 1 mM iodoacetic acid (IAA) produced contractions during an early period (5 to 10 min) and also a prolonged exposure (50 to 70 min). The early contraction was abolished by exposure to Ca -free media containing EGTA, and significantly attenuated by treatment with procaine or dantrolene. Verapamil, lidocai...

phenylmethanesulfonyl fluoride, and appeared to be unnecessary for the recognition. However, the modification of Arg residues with phenylglyoxal, His residues with diethylpyrocarbonate and sulfhydryl groups with 5,5'-dithiobis(2-nitrobenzoic acid), N-ethylmaleimide, iodoacetic acid or iodoacetamide showed that these residues were essential for the tRNA recognition by SerRS. Protection experimen...

SINCE Lundsgaard [1930] drew attention to the remarkably toxic nature of certain of the halogenacetic acids and their role as powerful and selective inhibitors of lactic acid formation and of alcoholic fermentation, these compounds have assumed great importance in physiology, and the numerous investigations of fundamental value to the theories of muscular contraction, tissue glycolysis and ferm...