Transcription factors are important targets for the treatment of a variety of malignancies but are extremely difficult to inhibit, as they are located in the cell’s nucleus and act mainly by protein-DNA and protein-protein interactions. The transcriptional regulators Id1 and Id3 are attractive targets for cancer therapy as they are required for tumor invasiveness, metastasis and angiogenesis. W...

Chronic kidney disease (CKD) affects the nonrenal clearance of drugs by modulating the functional expression of hepatic drug– metabolizing enzymes and transporters. The impact of CKD on oxidative and conjugative metabolism has been extensively studied. However, its effect on hepatic drug reduction, an important phase I drug–metabolism pathway, has not been investigated. We aimed to assess the e...

Sulfur segregation to the surface poses a perplexing problem in basic research on low surface area nickel materials. In addition sulfur effectively poisons catalytic reactions involving CO adsorption on nickel as well as other transition metal catalysts in technically important processes such as methanation and Fischer-Tropsch synthesis. It is not surprising then that considerable attention has...

The confrontation between General Relativity and experimental results, notably binary pulsar data, is summarized and its significance discussed. The agreement between experiment and theory is numerically very impressive. However, some recent theoretical findings (existence of non-perturbative strong-field effects, natural cosmological attraction toward zero scalar couplings) suggest that the pr...