Long Interspersed Elements (LINE-1s, L1s) are the most active mobile elements in the human genome and account for a significant fraction of its mass. The propagation of L1 in the human genome requires disruption and repair of DNA at the site of integration. As Barbara McClintock first hypothesized, genotoxic stress may contribute to the mobilization of transposable elements, and conversely, ele...

Abstract We investigated bidirectional cross-linguistic influence on motion event (ME) expressions in bilingual speakers of two typological different languages (Talmy’s typology), Spanish (as L1) and English L2). Specifically, we whether struggle to learn ME the L2, this process affects uses L1. Potential effects L2 proficiency AoA both L1 was also studied. elicited from 6-second video-clips we...

objective(s): to investigate the expression of human papilloma virus (hpv) l1 capsid protein, and human telomerase rna component (hterc) in cervical cancer and the role of detection of both genes in screening of cervical cancer.   materials and methods: a total of 309 patients were recruited and cervical exfoliated cells were collected. immunocytochemistry was employed to detect hpv l1 capsid p...

PURPOSE Recent observations have focused attention on the means that human tumors employ to evade host defense systems critical to immune surveillance. The concepts of immunotherapy are familiar to urologists because of the use of bacillus Calmette-Guérin in bladder cancer. Research demonstrating the importance of checkpoint inhibitors in suppressing immune responses against tumors has heighten...

Background: Programmed cell death protein-1 (PD-1)/PD-L1 pathway is one of the immune checkpoint pathways involved in regulation of the immune responses and suppression of anti-tumor defense. PD-1/B7-H1-blocking antibodies improve immune responses such as cytotoxic activity of CD8+/CD4+T cells and also increase mortality of tumor cells; however their use is accompanied by adverse effects in pat...

Abstract Previous research identified that studying texts in a second language (L2) as opposed to the first (L1) results substantially weaker recall. We hypothesized use of advance organizers (AOs) might attenuate this L2 recall cost by supporting users construction more solid memory representations. One hundred Dutch-English bilinguals studied two either L1 or L2, and with without help mind ma...

BACKGROUND AND PURPOSE Both pathogenic and regulatory immune processes are involved in the middle cerebral artery occlusion (MCAO) model of experimental stroke, including interactions involving the programmed death 1 (PD-1) receptor and its 2 ligands, PD-L1 and PD-L2. Although PD-1 reduced stroke severity, PD-L1 and PD-L2 appeared to play pathogenic roles, suggesting the use of anti-PD-L monocl...

The use of L1 regularisation for sparse learning has generated immense research interest, with many successful applications in diverse areas such as signal acquisition, image coding, genomics and collaborative filtering. While existing work highlights the many advantages of L1 methods, in this paper we find that L1 regularisation often dramatically under-performs in terms of predictive performa...

Abstract The use of the Spanish pronouns address tú and usted is an intricate matter for L2 learners due to many factors that influence their selection at discourse interactional level. Although literature has traditionally focused on challenges experienced by L1-English L2-Spanish in learning these forms, less known about speakers whose L1s also present similar (but not identical) address. Thi...