The role of Pseudomonas aeruginosa quorum-sensing systems in the lung infections associated with cystic fibrosis (CF) has not been examined. The purpose of this study was to determine if genes regulated by the LasR-LasI quorum-sensing system were coordinately regulated by the P. aeruginosa populations during the lung infections associated with CF. We also wanted to ascertain if there was a rela...

UNLABELLED The term of retrosternal or substernal goiter means that more than 50% of thyroid gland descends in the thorax. MATERIAL AND METHODS There is a retrospective study on retrosternal and substernal goiter and its patological features among 2482 patients who underwent thyroidectomy between 2000 and 2010 in the First Surgery Clinic of Iaşi. Retrosternal goiter was identified 54 patients...

Experiments examining the social dynamics of bacterial quorum sensing (QS) have focused on mutants which do not respond to signals and the role of QS-regulated exoproducts as public goods. The potential for QS signal molecules to themselves be social public goods has received much less attention. Here, we analyze how signal-deficient (lasI) mutants of the opportunistic pathogen Pseudomonas aeru...

The Pseudomonas aeruginosa quorum sensing signal molecule N-3-oxododecanoyl-l-homoserine lactone (3OC(12)HSL) can inhibit function of the mammalian anti-inflammatory transcription factor peroxisome proliferator activated receptor (PPAR)γ, and can be degraded by human paraoxonase (PON)2. Because 3OC(12)HSL is detected in lungs of cystic fibrosis (CF) patients infected with P. aeruginosa, we inve...

Penelitian ini menjelaskan tentang pengaruh bekerja dari rumah terhadap kinerja dan produktivitas karyawan di masa pandemi covid 19. mengambil sampel 91 responden lima kabupaten yang ada Solok yakni, Kubung, X Koto Diatas, Singkarak, Alahan Panjang, dan. Sungai Lasi. Metode digunakan pada penelitian yakni mixed method menggabungkan pendekatan kualitatif kuantitatif dengan alat Analisa menggunak...

Penelitian ini dilakukan berdasarkan hasil pengamatan penulis mengenai supervisi Kepala Sekolah Dasar Negeri Se Kecamatan IX Koto Sungai Lasi Kabupaten Solok masih belum terlaksana dengan optimal. Tujuan dari penelitian adalah untuk mendapatkan informasi dan memperoleh data tentang pandangan guru terhadap kepala sekolah yang dilihat indikator pengarahan, membantu memecahkan masalah, melaksanaka...

Biofilm microcolonies of Pseudomonas aeruginosa chronically infect the airways of patients with cystic fibrosis and fuel ongoing destructive inflammation, yet the impact of the switch from planktonic to biofilm growth on host responses is poorly understood. We report that in airway epithelial cells a threshold of p38α mitogen-activated protein kinase (MAPK) activation was required to trigger ne...