Lead exposure is higher among children with low socioeconomic status (SES) compared with other children in the United States. Low SES itself is a known risk factor for various diseases and dysfunctions, effects that have been ascribed to chronic stress and associated elevation of glucocorticoids. Chronically elevated glucocorticoids and Pb provoke similar behavioral changes, and both can act on...

Diabetes, a worldwide epidemic, represents a major public health problem and the vast majority of the patients with diabetes presents with insulin resistance, a fundamental manifestation of this disease. Insulin resistance impairs glucose uptake into skeletal muscle, which takes up about 80% of postprandial glucose in healthy individuals (1). Thus, skeletal muscle plays an indispensable role in...

The implantable cardioverter-defibrillator lead has undergone numerous design and manufacturing changes over the last 25 years aimed at improving patient care and outcomes. It is widely accepted that implantable cardioverterdefibrillator leads, similar to pacemaker leads, have a finite life. The design of an implantable cardioverter-defibrillator lead is more complex than that of a pacemaker le...

Differential inductive effects of lead on protein synthesis in rat fibroblasts and kidney epithelial cells were examined. The lead was administered as lead glutamate, a complex known to introduce lead into cells. Lead exposure induced the synthesis of three proteins which constitute two separate stress protein subgroups. Two of these proteins have been previously identified as the glucose-regul...

Lead toxicity is a public health problem particularly to the children and to occupationally exposed adults. Evidence is mounting successively regarding the adverse health effects of lead at low levels. This study was undertaken to assess the antioxidant status of lead-exposed residential and commercial painters of Lucknow city in Uttar Pradesh, India.Thirty-five painters aged 20 to 50 years who...

Much stress is of psychological origin and due to emotional arousal. The mechanisms by which anger, helplessness, or a sense of control and serenity exert their various neuroendocrine effects are discussed. Primacy is given to three systems; to the catecholamines, to testosterone and to cortisol. Evidence that they interact to accelerate the arteriosclerotic process is cited. The protective asp...

Medical curriculum can exposed the medical students to a significant levels of mental pressure. Therefore, the prevalence and incidence of psychiatric disorders including abnormal value of stress, depression and anxiety are higher in the schools of medicine. There are two major types of sources that can lead to stress and further mental problems in the medical students: 1. stresses related to t...

BACKGROUND Lead toxicity is a prevalent health problem in both developed and developing countries. One of the proposed mechanisms for lead-induced organ damage is oxidative stress. Oxidative stress is well-associated with the pregnancy disorder, pre-eclampsia. Exposure to lead may be one of the sources of the oxidative stress that leads to development of pre-eclampsia in pregnant women. OBJEC...