We consider the optimization problem of minimizing R Ω G(|∇u|) dx in the class of functions W (Ω), with a constrain on the volume of {u > 0}. The conditions on the function G allow for a different behavior at 0 and at ∞. We consider a penalization problem, and we prove that for small values of the penalization parameter, the constrained volume is attained. In this way we prove that every soluti...

BACKGROUND Perioperative hypertension affects 80% of cardiac surgery patients and is associated with an increased risk of complications. OBJECTIVE To determine the relationship between perioperative blood pressure (BP) control and hospital costs for cardiac surgery in the United States (US) and estimate the potential cost reductions associated with effective therapies. METHODS The analysis ...

• Si no sigue las instrucciones a continuación, la intervención de su hijo se retrasará o cancelará. • Controle a su hijo con cuidado para asegurarse de que no "consiga" comida. Controle que en el automóvil y en los asientos del automóvil no haya alimentos que puedan estar al alcance de su hijo. Instrucciones importantes sobre comidas y bebidas antes de la anestesia The ChIldren’s hospITal of p...

BACKGROUND In a randomized, comparative, clinical trial, caspofungin was found to be as effective as amphotericin B deoxycholate (ampho B) for treating candidemia (favorable outcomes in 71.7% and 62.8% of patients, respectively) and exhibited a generally better safety profile, particularly with respect to impaired renal function (IRF) (P = 0.02). OBJECTIVE The goal of this study was to examin...

1. Ecological conditions and constraints are considered to be important for the evolution of cooperative breeding. However, the importance of the costs of resource acquisition to the decision of subordinates to stay or leave and to help or not have been hardly studied experimentally. Here we reduced the overall food availability (zooplankton) for experimental populations of the cooperatively br...

Antibiotic resistance is often associated with metabolic costs. To investigate the metabolic consequences of antibiotic resistance, the genomic and transcriptomic profiles of an amoxicillin-resistant Escherichia coli strain and the wild type it was derived from were compared. A total of 125 amino acid substitutions and 7 mutations that were located <1,000 bp upstream of differentially expressed...

In a study in this issue of PLoS Medicine, Pieter van Baal and colleagues used data from The Netherlands to simulate the annual and lifetime medical costs attributable to obesity [1]. They also compared these costs to those attributable to smoking as well as to the medical costs associated with healthy, living persons (defined as non-smokers with a body mass index in the range of 18.5 to less t...