Background: Portulaca oleracea as a herbal plant has been widely used in traditional medicine to cure many diseases. The therapeutic effects of this plant are exerted through its active ingredients with antioxidant properties. It has been shown that this plant may have cytotoxic effects on cancer cells. In the present study, cytotoxic effects of aqueous extract of Portulaca oleracea on oral cav...

application of nanotechnology in medicinal and biological fields has attracted a great interest in the recent yeras. in this paper the cell membrane leakage induced by iron nanoparticles (fe-np) against pc12 cell line which is known as a model of nervous system cell line was investigated by the lactate dehydrogenase (ldh) test. therefore, pc12 cells were incubated with different concentration o...

background apoptosis or programmed cell death is an essential process for elimination of damaged cells. also, induction of apoptosis is fundamental for treating cancer. screening for agents that induce apoptosis in tumor cells help in the development of novel agents for cancer treatment. numerous studies suggest that the exposure of tumor cells to statins can lead to cell death via two separate...

objective: the existence of female germ-line stem cells (fgscs) has been the subject of a wide range of recent studies. successful isolation and culture of fgscs could facilitate studies on regenerative medicine and infertility treatments in the near future. our aim in the present study was evaluation of the most commonly used techniques in enrichment of fgscs and in establishment of the best p...

Introduction: Chronic myeloid leukemia (CML) is a malignant clonal disorder of hematopoietic stem cells resulting in the increase of myeloid cells, erythroid cells and platelets in the peripheral blood and hyperplasia in bone marrow. The research evaluated the cytotoxic effects of hydro-alcoholic extracts of Lepidium Sativum (Cress plant) shoots before and after flowering on K562 cell line as a...

objective(s): this study focused on determining cytotoxic effects of copper oxide nanoparticles (cuo nps) on chronic myeloid leukemia (cml) k562 cell line in a cell-specific manner and its possible mechanism of cell death. we investigated the cytotoxicity of cuo nps against k562 cell line (cancerous cell) and peripheral blood mononuclear cell (normal cell). materials and methods: the toxicity w...

In recent years, nanotechnology has gained serious attention for diagnosis, prevention and treatment roles. In this study we synthesized nanoceria or CeO2NPs (cerium oxide nanoparticles) and compared toxicity of cerium oxide powder in nano and bulk forms in two cancerous and one normal cell lines. The cell lines were cultured in a standard humidified incubator, at 37 °C in a 5% CO2 atmosphere, ...