OBJECTIVES Nonosmotic antidiuretic hormone (ADH) activity can cause severe hyponatremia during involuntary fluid administration. We looked for evidence of this before and during intravenous (IV) fluid administration in children treated for gastroenteritis. METHODOLOGY In this prospective observational study, plasma ADH, electrolytes, osmolality, and glucose were measured in 52 subjects before...

The axolotl, Ambystoma mexicanum, which has no specific calcium-containing sieve layer in the dermis, provides useful material for the study of the effect of Ca2+ on the development of amiloride-blockable active Na+ transport across the skin of amphibians. We raised axolotls in thyroid hormone or aldosterone or cultured the skin with corticoid plus one of several Ca2+ concentrations and found t...

The variations of glucose 6-phosphate dehydrogenase (G6PD) activity in different brain regions of normal, hypo- and hyperthyroid rats were investigated. Hypo- and hyperthyrodism were experimentaly induced by administration of methimazol and liothyronine, respectively. In normal rats, midbrain had the minimum (70 mU/mg) and cerebral cortex the maximum (349 mU/mg) G6PD activity. Hyperthyrodism in...

conclusions diclofenac-loaded nanoparticles based on properties of chitosan gelation could delay the release of drugs in the stomach and be further evaluated for the enteric delivery of diclofenac. objectives the aim of this study was to prepare and evaluate diclofenac-loaded chitosan nanoparticles based on the ionotropic gelation method. materials and methods chitosan (cs) nanoparticles contai...

Since the introduction of sensitive assays for serum thyroid-stimulating hormone (TSH) clinicians have advised hypothyroid patients to adjust dose levothyroxine (L-T4) in order achieve a normal TSH. A minority are dissatisfied with this treatment strategy and experience symptoms. Some indirect evidence suggests that TSH may not necessarily reflect euthyroidism at tissue level treated L-T4. Incr...

in order to evaluate the effect of liothyronine formulated by iran hormone co.(lt3,ih), 20 patients with primary hypothyroidism received 25mg lt3-ih daily. another 40 hypothyroids were randomly divided into 4 groups and entered a double blind clinical trail. two groups received 37.5 and 50mg ltrih and other two groups took 37.5 and 50mg cytomel (ltr skf). serum t4, t3 and tsh concentrations and...

Only two of the early genes of bacteriophage T7 were found to play a significant role in exclusion of superinfecting bacteriophage T3 particles; genes 0.3 and 1. Protein synthesis by the preinfecting phage particle was not required for efficient exclusion. These findings are discussed with regard to the known functions of these genes during T7 development.