Lipoprotein lipase (LPL) deficiency is a rare, hereditary disorder of lipoprotein metabolism characterised by severely increased triglyceride levels, and associated with an increased risk for pancreatitis. Since no adequate treatment modality is available for this disorder, we set out to develop an LPL gene therapy protocol. This paper focuses on the clinical presentation of LPL deficiency, sum...

Citation: Wang X, Wang Z, Bai X, Zhao Y, Zhang W and Lu X (2018) Deletion of a Gene Encoding a Putative Peptidoglycan-Associated Lipoprotein Prevents Degradation of the Crystalline Region of Cellulose in Cytophaga hutchinsonii. Front. Microbiol. 9:632. doi: 10.3389/fmicb.2018.00632 Deletion of a Gene Encoding a Putative Peptidoglycan-Associated Lipoprotein Prevents Degradation of the Crystallin...

background: serum lipids abnormalities have been observed in various forms of cancers including acute leukemia. investigators report decreased total cholesterol and hdl, and elevated triglyceride in leukemic patients. limited studies had been performed to discover the correlation between abnormal lipids profile and disease activity in leukemic patients in iran. this study was done to evaluate t...

abstract probiotic products highly affect the health of consumers by reducing the risk of heart attacks and improving of desirable microflora in intestinal tract. in this study the effect of yogurt (500g/d for 3 wk) enriched with either bifidobacterium bifidum or lactobacillus acidophilus on the level of cholesterol, low density lipoprotein (ldl) and high density lipoprotein (hdl) of serum and ...

background: the association between the lipid profiles level and the incidence and severity of coronary heart disease (chd) is very pronounced in epidemiological studies, and an inverse relation between physical fitness and the incidence of coronary heart disease has been observed in many studies. the aim of this study was to investigate the impact of a soccer match on lipid parameters of profe...

introduction: abnormal lipid profile causes maternal mortality and impairs fetal development. this study investigated the effect of ramadan fasting on plasma lipid profile in pregnant women. material and methods: this self-control, cohort study was performed in healthy volunteer fasted pregnant women. serum cholesterol, triglyceride (tg), low density lipoprotein (ldl), high density lipoprotein ...

BACKGROUND Genome-wide genetic association analysis represents an opportunity for a comprehensive survey of the genes governing lipid metabolism, potentially revealing new insights or even therapeutic strategies for cardiovascular disease and related metabolic disorders. METHODS AND RESULTS We have performed large-scale, genome-wide genetic analysis among 6382 white women with replication in ...

Objective(s): Stroke is the most common neurological disorder and genetic susceptibility has an important role in its etiology. Polymorphism in several genes such as lipoprotein lipase (LPL) is propounded as a risk for stroke. This meta-analysis investigated the association of rs285 and rs320 LPL polymorphism with stroke risk. Materials and Methods: We searched PubMed, Clarivate Analytics Web o...

Lipoprotein glomerulopathy is a rare kidney disease in which lipoprotein thrombi are seen in the glomerular capillaries. Most of these patients are found in Japan and East Asian countries. The presenting symptoms include proteinuria, an abnormal plasma lipoprotein profile that resembles type III hyperlipoproteinaemia, and a marked increase in serum apolipoprotein E concentration. Previous studi...

Lipoprotein subfractions help discriminate cardiometabolic disease risk. Genetic loci validated as associating with lipoprotein measures do not account for a large proportion of the individual variation in lipoprotein measures. We hypothesized that DNA methylation levels across the genome contribute to interindividual variation in lipoprotein measures. Using data from participants of the Geneti...