Background: Melatonin is a free radical scavenger. It has also antioxidant effects through its stimulatory actions on antioxidant system. Objective: We conducted this study to examine the effect of different oral doses of melatonin on liver tissue. Methods: We used 42 rats—6 rats in each group. Group I served as the control group; group II rats were pretreated with only melatonin; group III w...

the incidence of drug induced liver injury (dili) is about 1/1000 to 1/10000 among patients who receive therapeutic drug doses. drug induced hepatotoxicity is a major cause of acute and chronic liver disease. the severity of liver damage ranges from nonspecific changes in liver structure to acute liver failure, cirrhosis and liver cancer. some common agents that can cause liver injury are aceta...

Background: The aim of this study was to use Japanese quail as an animal model to evaluate the effects of cadmium (Cd) on the ultrastructure and the activity of metallothionein (MT) in the liver and kidneys. Methods: One hundred male Japanese quails were randomly divided into two Cd and control groups in 2015. The first group received 100 ppm Cd for 60 days in their feed. The ultrastructural c...