Non-alcoholic fatty liver lesion infection syndrome (NAFLD) is a kind of chronic stress factor parenchyma injury induced by lipid cell metabolism disorder, which mainly related to anti-insulin resistance disorder (IR) and hereditary alcohol-induced tactile disease. Its histological pathological changes include simple steatosis, nonalcoholic hepatitis fibrosis emerging after metabolic improvemen...

Regucalcin, which was discovered as a calcium-binding protein in 1978, has been demonstrated to play a multifunctional role as a suppressor in signaling transduction in various types of cells and tissues. Regucalcin has been shown to regulate intracellular calcium homeostasis, protein kinases and phosphatases, nitro oxide production, protein synthesis, gene expression, cell proliferation and ap...

Acid-base and potassium disorders occur frequently in the setting of liver disease. As the liver's metabolic function worsens, particularly in the setting of renal dysfunction, hemodynamic compromise, and hepatic encephalopathy, acid-base disorders ensue. The most common acid-base disorder is respiratory alkalosis. Metabolic acidosis alone or in combination with respiratory alkalosis also is co...

Alcohol use disorder is a significant health problem being a cause of increased morbidity and mortality worldwide. Alcohol-related illness has a relevant economic impact on the society and a negative influence on the life of patients and their family members. Psychosocial support might be useful in the management of people affected by alcohol use disorder since psychiatric and pharmaceutical ap...

Hepatic encephalopathy (HE) is a neuropsychiatric complication of acute and chronic liver disease. Its etiology and pathogenesis are thought to be a complex, metabolically induced, and therefore potentially reversible disturbance in brain functions. The diagnosis is based on demonstrating both a disorder of the central nervous system and a concomitant liver disease as well as the exclusion of a...

Alpha-1 antitrypsin deficiency is an inherited disorder that may cause severe lung and liver disease.

There is increasing evidence that fatty liver may be the most frequent liver disorder in Western countries. However, the epidemiology of fatty liver is still not fully understood and there is a clear need of better assessing and defining the potential role of the risk factors identified by clinical series in the general population. This article reviews the available data on the epidemiology of ...

introduction: constipation is one of the most common pediatric disorders.in many cases, there is no anatomic endocrineor metabolic cause in explanation of chronic constipation.more than 85% of them called functional or idiopathic.constipation is one of the serious disease in iranian traditional medicine. besides the problem it causes, chronic constipation can be the origin of many disease. that...

Celiac disease (CD) is an important cause of serum aminotransferase elevation: between 5 and 10% of patients with persistent and cryptogenetic transaminase elevation may have CD. In fact, a wide spectrum of liver injuries in children and adults may be related to CD, particularly: a) mild parenchymal damage characterized by absence of any clinical signs or symptoms suggesting chronic liver disea...

Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary disorder. Although liver involvement is the most frequent extra-renal manifestation, serious complications due to liver cysts are very rare. We report the occurrence of an acute abdomen caused by massive haemoperitoneum resulting from rupture of a giant liver cyst in ADPKD. Data suggest that chronic anticoagulation ther...