Abstract:Introduction: Patients with acute-on-chronic liver failure(ACLF) have different characteristics from those presented by non-ACLF patients diseases. The degree of ACLF impacts the outcome or without transplantation, divergences in literature, especially regarding post-transplant prognosis. Objectives: To review aspects ACLF, including concepts syndrome adopted various institutions, trea...

background the current organ shortage has prompted the use of marginal organs. we conducted this retrospective study to present our experience with transplanting deceased donor livers with elevated levels of serum transaminases and to explain whether elevated levels of serum transaminases in donors affect allograft function and survival of the recipients. methods data of deceased donor livers a...

conclusions in selected recipients with psc, dd reconstruction is a safe and efficacious technique, with long-term clinical outcomes comparable to ryh. background while roux-en-y hepaticojejunostomy (ryh) is the common anastomotic technique for liver transplantation (lt) in patients with primary sclerosing cholangitis (psc), duct-to-duct (dd) reconstruction may be used if the recipient common b...

stem cell-based therapies have recently opened up new horizons for treatment of various types of diseases including diabetes mellitus. however, long-term efficacy and safety of these novel modalities still remain a serious question. hereby, we aim to report the one-year follow-up results in the diabetic patients who underwent fetal liver-derived hematopoietic stem cell allotransplantation. fift...

conclusions although the patients carrying m204i mutation were more likely to show lack of responses to lam therapy, lam replacing by other nucleoside/tide analogs plus hbig maybe still effective in decreasing hepatitis b recurrence after liver transplantation. however, it is suggested that drug resistance test should be considered by clinicians during therapeutic management to avoid the follow...

Background: HCV chronic infection is a leading cause of end-stage liver disease and transplantation. The aim our study was to assess the benefits novel anti-HCV therapeutic approaches in obtaining viral clearance, reducing inflammation, regression fibrosis, improvement liver-related morbidity mortality.

Orthotopic liver transplantation is the preferred treatment for many patients with complications of end-stage liver disease. For metabolic liver diseases liver transplantation does not only replace the diseased organ, but also can potentially correct the metabolic defect. Results of liver transplantation for metabolic diseases have been encouraging. In Wilson's disease liver transplantation is ...

Hospital Physician March 2007 19 O rthotopic liver transplantation is a surgical procedure in which the diseased native liver is removed and replaced with all or part of a healthy liver obtained from a deceased or living human donor. The first liver transplantation was performed in 1963. Initially, overall outcomes were poor and liver transplantation remained experimental. Following advances in...

Graft steatosis has been associated with inferior outcomes after liver transplantation. Given the rising prevalence of obesity and fatty disease, strategies allowing safe successful utilization grafts are needed. Liver preservation by normothermic machine perfusion (NMP) allows reducing ischemia-reperfusion injury, extending time assessing graft viability prior to implantation into recipient. N...