considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (ua), a soluble salt of depleted uranium (du). we examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (bht), to prevent ua-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. beta-glucan (150 nm) and bht (20 nm) attenuated ua-indu...

Previous studies have demonstrated that excessive reactive oxygen/nitrogen species (ROS/RNS)‑induced apoptosis is an important feature of the injury to the lung epithelium in paraquat (PQ) poisoning. However the precise mechanisms of PQ‑induced dysfunction of the mitochondria, where ROS/RNS are predominantly produced, remain to be fully elucidated. Whether globular adiponectin (gAd), a potent m...

For asthma sufferers, contracting a lung infection can mean hospitalization, but it has never been clear how bugs exacerbate allergic conditions. Xu et al. (page 2907) now show that the major allergic inflammatory mediator— histamine—is also produced in response to infection. But it comes from an unexpected source. Mast cells together with basophils are considered the major producers of hista-m...

Abstract In severe cases of SARS-CoV-2 infection, death occurs as a result hypo-oxygenation peripheral tissues. The lung, severely damaged, can not ensure the transfer oxygen to blood. It is necessary increase alveolar concentration by supplementation, with or without mechanical ventilation. relatively poor outcomes are related fact that entire chain transport mitochondria compromised. capacity...

Considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (UA), a soluble salt of depleted uranium (DU). We examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (BHT), to prevent UA-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. Beta-glucan (150 nM) and BHT (20 nM) attenuated UA-indu...

For asthma sufferers, contracting a lung infection can mean hospitalization, but it has never been clear how bugs exacerbate allergic conditions. Xu et al. (page 2907) now show that the major allergic inflammatory mediator— histamine—is also produced in response to infection. But it comes from an unexpected source. Mast cells together with basophils are considered the major producers of hista-m...

when pooled immunoglobulin g (igg) from patients with multiple sclerosis (ms) was used to probe a human fetal spinal cord λgt 11 cdna library, the igg was found to bind to a predicted epitope of human mitochondrial nd4 sequence. to investigate the involvement of the nd4 as an autoantigen in ms, we determined the presence of specific antibody in the serum of ms patients and serum samples of some...