The inherent complexity of biological systems gives rise to complicated mechanistic models with a large number of parameters. On the other hand, the collective behavior of these systems can often be characterized by a relatively small number of phenomenological parameters. We use the Manifold Boundary Approximation Method (MBAM) as a tool for deriving simple phenomenological models from complic...

A decision support system (DSS) for systematic control of priority pollutants (PP) sources, based on economic activities and production (release) processes in urban catchments was recently developed. One of the crucial functionalities of the DSS is evaluation of source control measures, which is based on mathematical models, used for simulating the fate of the PPs in urban catchments under diff...

the majority of patients with glioblastoma multiforme (gbm) suffer dismal outcomes. adopting a broader, multi-mechanistic, multi-agent approach targeting gbm using readily available and fairly benign agents in combination with standard therapy may improve outcomes. such agents include fluoxetine, fenofibrate, cimetidine, citrulline, valacyclovir, 1,3 1-6 beta glucan, and tadalafil, among others...

Eukaryotic cells integrate information from multiple sources to respond appropriately to changes in the environment. Here, we examined the relationship between two signaling pathways in Saccharomyces cerevisiae that are essential for the coordination of cell growth with nutrient availability. These pathways involve the cAMP-dependent protein kinase (PKA) and Tor proteins, respectively. Although...

Mammalian target of rapamycin (mTOR, now referred to as mechanistic target of rapamycin) is considered as the master regulator of cell growth. A definition of cell growth is a build-up of cellular mass through the biosynthesis of macromolecules. mTOR regulation of cell growth and cell size is complex, involving tight regulation of both anabolic and catabolic processes. Upon a growth signal inpu...