High impact polystyrene (HIPS)/corn starch blends were prepared in presence of glycerol as a plasticizer via melt extrusion process by a twin-screw extruder. The novelty of this work is first, because of the use of pre-gelatinized corn starch as modified one and second, the procedure of making blends by extruder which makes it ease of access and also industrially possible. The blends were then ...

The viscoelastic character of polymer solutions and melts gives rise to instabilities that are not seen in the flows of Newtonian liquids. In industrial applications such as coating and extrusion, these so-called “elastic” instabilities can impose a limitation on the throughput. Hence, it is important to understand, and if possible, to suppress them. The first instability we study is the phenom...

The objective of this study was to determine if a high Tg polymer (Eudragit(®) S100) could be used to stabilize amorphous domains of polyethylene oxide (PEO) and hence improve the stability of binary polymer systems containing celecoxib (CX). We propose a novel method of stabilizing the amorphous PEO solid dispersion through inclusion of a miscible, high Tg polymer, namely, that can form strong...

In order to improve the aqueous solubility and dissolution of Tacrolimus (TAC), amorphous solid dispersions of TAC were prepared by hot melt extrusion with three hydrophilic polymers, Polyvinylpyrrolidone vinyl acetate (PVP VA64), Soluplus® and Hydroxypropyl Cellulose (HPC), at a drug loading of 10% w/w. Molecular modeling was used to determine the miscibility of the drug with the carrier polym...

A two-step strain-induced melt activation (TS-SIMA) process that omits the cold working step of the traditional strain-induced melt activation (SIMA) process is proposed for 6066 Al-Mg-Si alloy to obtain fine, globular, and uniform grains with a short-duration salt bath. The results show that increasing the salt bath temperature and duration leads to a high liquid phase fraction and a high degr...

OBJECTIVES The aim of this study was to develop mucoadhesive oral strips using hot-melt extrusion as a continuous manufacturing process. METHODS Powder blends of ketoconazole, a water-insoluble drug - either hydroxypropyl methylcellulose (HPMC) or soluplus (SOL), sorbitol (SRB) and magnesium aluminometasilicate (MAS) were extruded to manufacture thin strips with 0.5-mm thickness. The presence...

Melt Electrowriting In article number 2209244, Carlos Sánchez-Somolinos and co-workers report on the melt electrowriting of liquid crystal elastomers to digitally position ultrafine fibers with controlled morphology. The presented methodology enables preparation well-defined, high-aspect-ratio scaffolds small dimensions hardly accessible conventional extrusion-based printing techniques. This pl...

A two part study utilizing isotactic poly(4 -methyl-1-pentene) (PMP) was undertaken to investigate a three stage process (melt-extrusion/annealing/uniaxial-stretching) (MEAUS) to produce microporous films. In this report, the thermal annealing (second stage) and subsequent uniaxial-stretching (third stage) results of selected PMP films from three resins, labeled A, B & C, are discussed. From se...

The holt-melt extrusion technique has proven to be an advantageous method for preparation of solid dosage forms. The aim of this work was to evaluate the release profiles of sustained release cylinders produced by hot-melt extrusion. The cylinders were composed of inner and outer part, both containing theophylline [1]. Cylinders were 0.5cm or 1cm long. The two parts were extruded separately, cu...

The aim of this study was to evaluate the suitability of Raman spectroscopy as a Process Analytical Technology (PAT) tool for the in-line determination of the active pharmaceutical ingredient (API) concentration and the polymer-drug solid state during a pharmaceutical hot-melt extrusion process. For in-line API quantification, different metoprolol tartrate (MPT)--Eudragit® RL PO mixtures, conta...