Background After the introduction of highly active antiretroviral therapy for the treatment of HIV infection, metabolic abnormalities were increasingly observed, associated with both protease inhibitors and nucleoside reverse transcriptase inhibitors, characterized by abnormal fat distribution in the body (lipoatrophy, lipohypertrophy or both), hyperglycemia and lean tissue mass wasting. Howeve...

BACKGROUND Among breast cancers, the triple-negative breast cancer (TNBC) subtype has the worst prognosis with no approved targeted therapies and only standard chemotherapy as the backbone of systemic therapy. Unique metabolic changes in cancer progression provide innovative therapeutic opportunities. The receptor tyrosine kinases (RTKs) epidermal growth factor receptor (EGFR), and MET receptor...

diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. the management of the blood glucose level is a critical strategy in the control of diabetes complications. inhibitors of carbohydrate hydrolyzing enzymes have been useful as oral hypoglycemic drugs for the control of hyperglycemia especially in patients with type ii disables mellitus. the goal of the present study...

BACKGROUND Type 2 diabetes mellitus (T2DM) is a progressive chronic disease associated with severe microvascular and macrovascular complications. Our aim is to assess the real world effectiveness of SGT" inhibitors in achieving metabolic therapeutic goals. METHODS A retrospective, observational study. Inclusion criteria for patients were a previous diagnosis of type 2 diabetes mellitus, age >...

On behalf of the 48 coauthors from our article reporting the findings and recommendations of the 2nd Diabetes Surgery Summit (DSS-II) (1), we sincerely thank Aberle and Göke (2) for their insightful comments about the consideration of sodium–glucose cotransporter 2 (SGLT2) inhibitors to treat type 2 diabetes (T2D) shortly after bariatric/metabolic surgery. The DSS-II was a consensus development...

Diabetic patients are at high risk for mortality after contracting several infections. Additionally, diabetes has been mentioned as an independent factor progression to severe disease in seasonal influenza and in-hospital deaths due coronavirus 2019 (COVID-19). ketoacidosis is a well-known complication of type-1 characterized by hyperglycemia, metabolic acidosis, ketone levels. Euglycemic diabe...

conclusions adherence to the meddiet, according to mds and sofi-mds, may not predict mets components and mets incidence after 3 years of follow-up in iranian adult populations. results after adjusting for potential confounders, neither higher mds nor higher sofi-mds were significantly associated with the mean values of mets components and the risk of metabolic abnormalities incidence after 3 ye...