In the title compound, C(11)H(17)ClNO(+)·NO(3) (-), the side chain of the ethyl-ammonium group is orientated approximately perpendicular to the benzene ring, the dihedral angle between the C/C/N plane of the ethyl-ammonium group and the benzene ring being 79.40 (18)°. In the crystal structure, inter-molecular O-H⋯O and N-H⋯O hydrogen bonds are observed between the cation and the anion.

Fumiko Hoeft,1 Arvel Hernandez,1 Glenn McMillon,1 Heather Taylor-Hill,1 Jennifer L. Martindale,1 Ann Meyler,2 Timothy A. Keller,2 Wai Ting Siok,1 Gayle K. Deutsch,1 Marcel Adam Just,2 Susan Whitfield-Gabrieli,1 and John D. E. Gabrieli1 1Department of Psychology, Stanford University, Palo Alto, California 94305-2130, and 2Center for Cognitive Brain Imaging, Department of Psychology, Carnegie Mel...

The purified and lipid-reconstituted plasma m e m b r a n e A T P a s e o f the y e a s t Schizosaccharomyces pombe, which is believed to function as an electrogenic proton pump, is shown to be sensitive to seven different inhibitors. Most of the inhibition kinetics yields straight lines when analyzed by the graphical methods of Lineweaver-Burk ( l / u uersus l / [q) , Dixon ( l /u uersus [Q),...

In this work, O/W emulsion sets were prepared by using different concentrations of two nonionic surfactants. The two surfactants, tween 80(HLB=15.0) and span 80(HLB=4.3) were used in a fixed proportions equal to 0.55:0.45 respectively. HLB value of the surfactants blends were fixed at 10.185. The surfactants blend concentration is starting from 3% up to 19%. For each O/W emulsion set the conduc...

A reverse phase high performance liquid chromatography method was developed to estimate Miconazole nitrate and Clobetasol propionate simultaneously from a cream formulation. The validated as per International Council for Harmonisation guidelines. proposed effectively applied the characterization of degradation products formed under hydrolytic stressed conditions. major degradants by hydrolysis ...

backgrounds candida vaginitis is a common fungal infection among adult women and it has been estimated that 75% of all adult women experience at least one period of vulvovaginal candidiasis in their lifetime. several predisposing factors, such as diabetes mellitus,using contraceptive, pregnancy, and broad-spectrum antibiotics are reported as main risk factors for the infection. while, the main ...

Mucosal biofilm-related fungal infections are very common, and the incidence of recurrent oral and vulvovaginal candidiasis is significant. As resistance to azoles (the preferred treatment) is occurring, we aimed at identifying compounds that increase the activity of miconazole against Candida albicans biofilms. We screened 1,600 compounds of a drug-repositioning library in combination with a s...

A simple, rapid and precise gas chromatographic method has been developed for the simultaneous determination of miconazole nitrate (MIZ) and metronidazole (MNZ) in tablets and ovules, using a capillary column AE.SE-54 (15 m × 0.53 mm, i.d.) and nitrogen as a carrier gas at a flow rate of 9 mL min(-1). The oven temperature was programmed at 140°C for 3 min, with a rise of 40°C min(-1) up to 180°...

The aim of this study is to examine the physicochemical properties of the external preparation, the effect on the skin permeability and the human senses. Miconazole nitrate cream formulation (MCZ-A: bland name and MCZ-B, -C, -D: generics) to measure the physicochemical properties, was performed by the skin permeation test and human sensory test. The flattening, viscoelasticity, and water conten...