Wound healing continues to pose a challenge in clinical settings. Moreover, wound management must be performed properly and efficiently. Acute involves multiple cell divisions, new extracellular matrix, the process of formation, such as growth factors cytokines, which are released at site regulate process. Any changes that disrupt could cause tissue damage prolong Various factors, microbial inf...

The notion that the colon's deep crypt pockets provide a protected location that shields stem cells from potentially toxic substances is widely accepted. In this issue of Cell, Kaiko et al. reveal how a metabolite abundantly produced by the gut microbiota can inhibit stem cell proliferation but is blocked from doing so by crypt architecture.

We evaluated the abundance of microbial functional groups involved in compost fertility, and the chemical parameters of maturity and quality most commonly analyzed in compost products. We employed compost produced using the same hydrolytic stage and two maturation processes (with and without earthworms) and with different organic wastes. Our aim was to propose a valid tool for measuring the qua...

In order to mimic the human metabolic pathway of cyclosporin A (CyA) a total of 28 bacterial and 72 fungal strains was screened for their ability to transform CyA. Among 3 bacteria and 11 fungi, which produced the main human metabolite OL-17 [eta HyMeBmt1]CyA, Actinoplanes sp. (ATCC 53771) achieved the best transformation rate (5.4%). Furthermore, the two N-demethylated minor products [Leu4]CyA...

Leptomycin B (LMB), a secondary metabolite produced by Streptomyces sp. strain ATS 1287, with known antifungal and antitumor effects, inhibits the nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 regulatory protein Rev and exhibits significant antiproliferative activity. Since LMB itself turned out to be distinctly cytotoxic, a bioconversion screening with a selected ...