نتایج جستجو برای: mir 125b

تعداد نتایج: 45469  

2017
Li-Li Mei Wen-Jun Wang Yun-Tan Qiu Xiu-Feng Xie Jie Bai Zhi-Zhou Shi

MicroRNAs (miRNAs) play important roles in the progression of human cancer including esophageal squamous cell carcinoma (ESCC). Although previous reports showed that miR-125b-5p was down-regulated in ESCC, the roles and mechanisms of loss of function of miR-125b-5p in ESCC were still unknown. Using microRNA microarray and GEO datasets, we found and confirmed that miR-125b-5p was down-regulated ...

Journal: :International journal of cancer 2011
Yi Guan Hailan Yao Zhihong Zheng Guangrong Qiu Kailai Sun

Micro-RNAs (miRNAs) important for post-transcriptional gene expression as negative regulators are endogenous 21- to 23-nucleotide noncoding RNAs. Many miRNAs are expressed in ovarian cancer (OC). In this study, we reported that miR-125b was underexpressed in human OC specimens. Ectopic expression of miR-125b in OC cells induced cell cycle arrest and led to reduction in proliferation and clonal ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
A G Lisa Ooi Debashis Sahoo Maddalena Adorno Yulei Wang Irving L Weissman Christopher Y Park

MicroRNAs profoundly impact hematopoietic cells by regulating progenitor cell-fate decisions, as well as mature immune effector function. However to date, microRNAs that regulate hematopoietic stem cell (HSC) function have been less well characterized. Here we show that microRNA-125b (miR-125b) is highly expressed in HSCs and its expression decreases in committed progenitors. Overexpression of ...

2016
Maria Lee Eun Jae Kim Myung Jae Jeon

The aim of the present study was to identify the specific miRNAs involved in regulation of EIF4EBP1 expression in ovarian cancer and to define their biological function. miRNA mimics and miRNA inhibitors were used in quantitative PCR, western blotting, and luciferase reporter assays to assess cell migration, invasiveness, and viability. miR-125a and miR-125b were downregulated in ovarian cancer...

2017
Sabyasachi Dash Muthukumar Balasubramaniam Tanu Rana Arthur Godino Emily G Peck Jeffery Shawn Goodwin Fernando Villalta Erin S Calipari Eric J Nestler Chandravanu Dash Jui Pandhare

Cocaine exposure alters gene expression in the brain via methylation and acetylation of histones along with methylation of DNA. Recently, poly (ADP-ribose) polymerase-1 (PARP-1) catalyzed PARylation has been reported as an important regulator of cocaine-mediated gene expression. In this study, we report that the cellular microRNA "miR-125b" plays a key role for cocaine-induced PARP-1 expression...

2015
Hui Chen Zhiying Xu

BACKGROUND MicroRNAs (miRNAs) have been found to be downregulated in human colorectal cancer (CRC), and some of them may function as tumor suppressor genes (TSGs). Aberrant methylation triggers the inactivation of TSGs during tumorigenesis. PATIENTS AND METHODS We investigated the methylation status of miR-125 family in CRC tissues and adjacent nontumor tissues by using bisulfite sequencing P...

2014
Qiang Fu Zheng Liu Deng Pan Weijuan Zhang Le Xu Yu Zhu Haiou Liu Jiejie Xu

The present study aims to evaluate the impact of tumor microRNA-125b (miR-125b) on recurrence and survival of patients with clear-cell renal cell carcinoma (ccRCC) following surgery. We retrospectively enrolled 276 patients (200 in the training cohort and 76 in the validation cohort) with ccRCC undergoing nephrectomy at a single institution. Clinicopathologic features, cancer-specific survival ...

Journal: :Molecular cancer research : MCR 2009
Marco H Hofmann Jochen Heinrich Gerald Radziwill Karin Moelling

The noncoding RNA miR-125b has been described to reduce ErbB2 protein expression as well as proliferation and migration of cancer cell lines. As additional target of miR-125b, we identified the c-raf-1 mRNA by sequence analysis. We designed a short hairpin-looped oligodeoxynucleotide (ODN) targeted to the same 3' untranslated region of c-raf-1 mRNA as miR-125b. The fully complementary ODN antis...

2015
Xiao-Qing Ding Peng-Cheng Ge Zhe Liu Heng Jia Xi Chen Feng-Hui An Li-Hua Li Zhao-Hong Chen Hong-Wei Mao Zhao-Yang Li Yan Gu Tie-Bing Zhu Chun-Jian Li Lian-Sheng Wang Wen-Zhu Ma Zhi-Jian Yang En-Zhi Jia

The aim of this study was to identify the synergistic effect of microRNA expression with classical risk factors of coronary heart disease (CHD) and to explore their diagnostic value for coronary stenotic lesions in subjects with CHD. Plasma samples were obtained from 66 subjects with CHD and from 58 control individuals. A quantitative reverse-transcription PCR (RT-qPCR) assay was conducted to c...

2017
Xinfeng Yu Wenna Shi Yuhang Zhang Xiaohui Wang Shiyue Sun Zhiyu Song Man Liu Qiao Zeng Shuxiang Cui Xianjun Qu

The activation of CXCL12/CXCR4 axis is associated with potential progression of cancer, such as invasion, metastasis and chemoresistance. However, the underlying mechanisms of CXCL12/CXCR4 axis and cancer progression have been poorly explored. We hypothesized that miRNAs might be critical downstream mediators of CXCL12/CXCR4 axis involved in cancer invasion and chemoresistance in CRC. In human ...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید