نتایج جستجو برای: mir 125b

تعداد نتایج: 45469  

Journal: :iranian journal of basic medical sciences 0
pan-feng wu department of orthopaedics, xiang ya hospital, central south university, changsha 410008, china jie-yu liang department of orthopaedics, xiang ya hospital, central south university, changsha 410008, china fang yu department of orthopaedics, xiang ya hospital, central south university, changsha 410008, china zheng-bing zhou department of orthopaedics, xiang ya hospital, central south university, changsha 410008, china ju-yu tang department of orthopaedics, xiang ya hospital, central south university, changsha 410008, china kang-hua li department of orthopaedics, xiang ya hospital, central south university, changsha 410008, china

objective(s):mir-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (gct) of bone remains poorly understood. the current study aimed to investigate the potential role and mechanism of mir-125b in gct. materials and methods:expression levels of mir-125b in gct tissues were determined using rt-pcr. the cell proliferation was surveyed by direct cell coun...

Objective(s):miR-125b has been identified as a tumor suppressor in many tumors, but its role in giant cell tumor (GCT) of bone remains poorly understood. The current study aimed to investigate the potential role and mechanism of miR-125b in GCT. Materials and Methods:Expression levels of miR-125b in GCT tissues were determined using RT-PCR. The cell proliferation was surveyed by direct cell coun...

Journal: :International journal of oncology 2011
Naohiro Nishida Takehiko Yokobori Koshi Mimori Tomoya Sudo Fumiaki Tanaka Kohei Shibata Hideshi Ishii Yuichiro Doki Hiroyuki Kuwano Masaki Mori

MicroRNAs (miRNAs) are small, non-coding RNAs that can function as oncogenes or tumor suppressors in human cancer. Recent reports have highlighted the oncogenic aspects of microRNA miR-125b. However, the clinical significance of miR-125b in gastrointestinal cancers has not been sufficiently investigated. To this end, we analyzed miR-125b expression in colorectal cancer cases. Quantitative RT-PC...

Journal: :Blood 2017
Jun Liu Bo Guo Zhuo Chen Nayi Wang Michelina Iacovino Jijun Cheng Christine Roden Wen Pan Sajid Khan Suning Chen Michael Kyba Rong Fan Shangqin Guo Jun Lu

The hematopoietic stem cell-enriched miR-125 family microRNAs (miRNAs) are critical regulators of hematopoiesis. Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads to expansion of hematopoietic stem cells accompanied by perturbed hematopoiesis with mostly myeloproliferative phenotypes. However, whether a...

2017
Xinghua Zhang Xiao Ma Huaying An Changqing Xu Wenjo Cao Wei Yuan Jie Ma

Although there are reports of miR-125b being dysregulated in colorectal cancer (CRC) and associated with CRC progression, little is known about its intrinsic regulatory mechanisms. Here we detected the expression of miR-125b in CRC tissues, subsequently investigated the effect of miR-125b on the proliferation, apoptosis, cell cycle and metastasis on CRC cells. Our results showed that the expres...

2016
Zixing Liu Kelly R. Smith Hung T. Khong Jingshan Huang Eun-Young Erin Ahn Ming Zhou Ming Tan

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematopoietic malignancy. Although it has been reported that overexpression of miR-125b leads to T-ALL development, the underlying mechanisms of miR-125b action are still unclear. The goal of this study is to delineate the role of miR-125b in T-ALL development. We found that miR-125b is highly expressed in undifferentiated leukemic T ...

Journal: :Blood 2012
Esmerina Tili Jean-Jacques Michaille Zhenghua Luo Stefano Volinia Laura Z Rassenti Thomas J Kipps Carlo M Croce

MiR-125b-1 maps at 11q24, a chromosomal region close to the epicenter of 11q23 deletions in chronic lymphocytic leukemias (CLLs). Our results establish that both aggressive and indolent CLL patients show reduced expression of miR-125b. Overexpression of miR-125b in CLL-derived cell lines resulted in the repression of many transcripts encoding enzymes implicated in cell metabolism. Metabolomics ...

Journal: :Cancer research 2011
Yan Zhang Li-Xu Yan Qi-Nian Wu Zi-Ming Du Jing Chen Ding-Zhun Liao Ma-Yan Huang Jing-Hui Hou Qiu-Liang Wu Mu-Sheng Zeng Wen-Lin Huang Yi-Xin Zeng Jian-Yong Shao

The microRNA miR-125b is dysregulated in various human cancers but its underlying mechanisms of action are poorly understood. Here, we report that miR-125b is downregulated in invasive breast cancers where it predicts poor patient survival. Hypermethylation of the miR-125b promoter partially accounted for reduction of miR-125b expression in human breast cancer. Ectopic restoration of miR-125b e...

2012
Chao Shang Yan-ming Lu Li-rong Meng

BACKGROUND MicroRNAs (miRNAs) are small non-coding nucleotides that regulate mRNA stability and protein expression by imperfect base pairing with the 3'-untranslated region (3'UTR) of target mRNAs. Many miRNAs have been documented to be aberrantly expressed in human cancers, but the role of miRNAs in endometrioid endometrial cancer (EEC) remains poorly understood. The objective of this study wa...

2015
JIPENG LI LAIFU FANG WANJUN YU YIPING WANG

MicroRNAs (miRNAs) are a class of small non-coding RNA molecules that serve an important function in carcinogenesis and tumor progression. The present study investigated the roles and mechanisms of miRNA-125b (miR-125b) in human hepatocellular carcinoma (HCC). miR-125b was significantly downregulated in the examined HCC tissues and cell lines. Overexpression of miR-125b reduced HCC cell migrati...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید