Computational conformational sampling is integral to small molecule pharmaceutical research, for detailed conformational analysis and high-throughput 3D library enumeration. These two regimes were tested in details for the general-purpose modeling program MOE, using its three conformational sampling methods, i.e. systematic search, stochastic search, and Conformation Import. The tests include i...

BACKGROUND The prevalence of mental depression has increased in recent years, and has become a serious health problem in most countries of the world, including India. Due to the high cost of antidepressant synthetic drugs and their accompanying side effects, the discovery of safer antidepressant herbal remedies is on the rise. Moringa oleifera (MO) (drumstick) has been used in traditional folk ...

The semi-aquatic lifestyle of amphibians represents a unique opportunity to study the molecular driving forces involved in the transition of aquatic to terrestrial olfaction in vertebrates. Most amphibians have anatomically segregated main and vomeronasal olfactory systems, but at the cellular and molecular level the segregation differs from that found in mammals. We have recently shown that am...

a MOE Key Laboratory of Western China's Environmental Systems, Research School of Arid Environment and Climate Change, Lanzhou University, Lanzhou 730000, China b MOE Key Laboratory of Arid and Grassland Ecology, Lanzhou University, Lanzhou 730000, China c Nicholas School of the Environment, Duke University, Durham, North Carolina 27708, USA d Department of Ecology, College of Urban and Environ...

In order to lower costs, the fabrication of Integrated Circuits (ICs) is increasingly delegated offshore contract foundries, making them exposed malicious modifications, known as hardware Trojans. Recent works have demonstrated that a strong form Trojan-resilience can be obtained from untrusted chips by exploiting secret sharing and Multi-Party Computation (MPC), yet with significant cost overh...

March 2004 1527-3342/04/$20.00©2004 IEEE Andreas F. Molisch ([email protected]) is with Mitsubishi Electric Research Labs, 201 Broadway, Cambridge, MA 02139 USA and also with the Department of Electrosicence, Lund University, Lund, Sweden. Moe Z. Win is with the Laboratory for Information and Decision Systems (LIDS), Massachusetts Institute of Technology, Cambridge, MA 02139 USA. Andreas...

In the mouse, odorant receptor proteins (ORs) are G-protein-coupled receptors expressed in mature olfactory sensory neurons (OSNs) of the main olfactory epithelium (MOE). ORs mediate odorant reception at the level of the OSN cilia. Most of the ∼1100 OR genes in the mouse genome are expressed, at the RNA level, in mature OSNs. The literature on antibodies against ORs is limited, and most reports...

The mammalian main olfactory epithelium (MOE) modifies its activities in response to changes in the chemical environment. This process is essential for maintaining the functions of the olfactory system and the upper airway. However, mechanisms involved in this functional maintenance, especially those occurring via paracrine regulatory pathways within the multicellular MOE, are poorly understood...