In this paper, dynamic MOE and static MOE of short-length radiata pine specimens produced for finger jointing were measured using non-destructive technique and correlated to each other. In order to obtain reliable static MOE data, 36 mm thickness shooks as well as the matched samples of reduced thickness (15mm) were tested, and the effect of annual growth rings on dynamic and static MOE is also...

High-grade serous carcinoma (HGSC) is the most lethal ovarian cancer histotype. The fallopian tube secretory epithelial cells (FTSECs) are a proposed progenitor cell type. Genetically altered FTSECs form tumors in mice; however, a spontaneous HGSC model has not been described. Apart from a subpopulation of genetically predisposed women, most women develop ovarian cancer spontaneously, which is ...

Polarization is a common feature of many types of cells, and we are beginning to understand how cells become polarized. The role of cell polarity in development and tissue morphogenesis, however, is much less well understood. Our previous analysis of the mosaic eyes (moe) mutations revealed that moe is required for retinal lamination and also suggested that zebrafish moe function is required in...

Establishment of apical-basal cell polarity has emerged as an important process during development, and the Crumbs complex is a major component of this process in Drosophila. By comparison, little is known about the role of Crumbs (Crb) proteins in vertebrate development. We show that the FERM protein Mosaic Eyes (Moe) is a novel regulatory component of the Crumbs complex. Moe coimmunoprecipita...

How the mitosis of neuroepithelial stem cells is restricted to the apical ventricular area remains unclear. In zebrafish, the mosaic eyes(rw306) (moe/epb41l5(rw306)) mutation disrupts the interaction between the putative adaptor protein Moe and the apicobasal polarity regulator Crumbs (Crb), and impairs the maintenance of neuroepithelial apicobasal polarity. While Crb interacts directly with No...

Phosphorothioate (P=S) antisense oligonucleotides (ASO) targeting the cell survival gene clusterin synergistically enhance castration- and chemotherapy-induced apoptosis in prostate cancer xenografts. This study compares efficacy, tissue half-lives, and toxicity of P=S clusterin ASO to third-generation backbone 2'-O-(2-methoxy)ethyl (2'MOE) ribose-modified clusterin ASO. Northern analysis quant...

This study investigates the impact of adhesive spread rates and lamina assembly patterns on physical mechanical properties glue laminated lumber (glulam) manufactured from Kelempayan wood (Neolamarckia cadamba (Roxb.) Bosser). For this purpose, lab-scale 3-ply homogenous glulams were using low-MOE, average-MOE, high-MOE laminas, mixed low-high-low-MOE high-low-high-MOE lamina, with an rate 100 ...

Fundamental to the project's success was acceptance of MOE/MAR by UHN's physicians, yet many physicians questioned whether MOE/MAR would impede their ability to care for their patients. To ensure physician adoption, UHN presented MOE/MAR as a patient safety initiative from the beginning.