the emergence of multidrug resistant strains of escherichia coli has complicated treatment decision and may lead to treatment failures. from april to november 2001 we prospectively evaluated the prevalence of resistance to trimethoprim-sulfamethoxazole (sxt), gentamicin, cephalothin, ciprofloxacin, and nitrofurantoin in 220 escherichia coli isolates from patients with urinary tract infections i...

BACKGROUND To investigate the mechanisms of multidrug resistance of brain tumors, to identify the site of cellular expression of P-gp in human brains in situ and to morphologically determine whether an association may exist between P-gp and caveolin-1. METHODS Immunohistochemistry was used to detect the expression and location of P-glycoprotein (P-gp), multidrug resistance-associated protein ...

conclusions the hai prevalence found in this study was lower than hai rates reported in some other studies from iran. the isolates showed high resistance to common antibiotics. guidelines for improving hai surveillance and stringent measures to reduce the prevalence of multidrug-resistant hais must be implemented to reduce the rate and the consequences of hais. results a total of 16,140 patient...

PURPOSE Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a tumor suppressor gene and may be related to tumor drug resistance. In this study, we explored whether LRIG1 protein expression can improve the chemosensitivity of glioma cells and what was its mec...

Bacterial infections may cause disease and death. Infants and children are often subject to bacterial infections. Antimicrobials kill bacteria protecting the infected patients andreducing the risk of morbidity and mortality caused by bacteria. The antibiotics may lose their antibacterial activity when they become resistant to a bacteria. The resistance to different antibiotics in a bacteria is ...

background and objective:acinetobacter spp.a gram-negative coccobacillus is increasingly reported as important cause of nosocomial infections. multi-drug resistance (mdr) ofacinetobacterspp., raises concerns over our ability to treat serious infections with these organisms. the aim of this study was to determine the frequency and associated risk factors for infections with mdr acinetobacter spp...

background and objectives: β-lactamase production is the predominant mechanism for resistance to β-lactams in enterobacteriaceae. the producing isolates are often multidrug resistant and are major hosts for extended spectrum β-lactamases. this study was designed to determine the prevalence of extended-spectrum β-lactamase producing isolates of escherichia coli and klebsiella pneumoniae and thei...

Drug resistance is the leading cause of death in prostate cancer patients. Therefore, exploring mechanism underlying drug and identifying novel therapeutic targets are urgently needed. Long non-coding ribonucleic acid disrupted renal carcinoma 3 acts as a tumor suppressor gene several types. However, to date, no study has investigated biological function long cancer. Gene expression was detecte...