conclusions metronidazole and vancomycin still seem to be most effective drugs for treatment cdi. objectives the aim of this study was to investigate the antimicrobial susceptibility patterns of c. difficile clinical isolates against antibiotics commonly used for treatment cdi in hospitalized patients. material and methods during a 12 month study, 75 c. difficile isolates were collected from 39...

UNLABELLED Bacterial antibiotic efflux pumps are key players in antibiotic resistance. Although their role in conferring multidrug resistance is well documented, the emergence of "super" efflux pump variants that enhance bacterial resistance to multiple drugs has not been reported. Here, we describe the emergence of a resistance-enhancing variant (named RE-CmeABC) of the predominant efflux pump...

Prevalence of mecA, blaZ, tetO/K/M, ermA/B/C, aph, and vanA/B/C/D genes conferring resistance to oxacillin, penicillin, tetracycline, erythromycin, gentamicin, and vancomycin was investigated in 65 staphylococcal isolates belonging to twelve species obtained from ready-to-eat porcine, bovine, and chicken products. All coagulase negative staphylococci (CNS) and S. aureus isolates harbored at lea...

and people with permanent prostheses. its increased resistance to antibiotics has created a serious challenge for healthcare system. this study was conducted to determine the pattern of antibiotic-resistance of s. epidermidis isolates from clinical samples.   methods :   during nine months, 251 clinical samples isolated from strains of s. epidermidis were examined. following identification of i...

Objective: This review discusses the impact of antibiotic resistance in the intensive care unit (ICU), including the prevalence, morbidity, antibiotic resistance patterns and factors perpetuating antibiotic resistance. In addition, this describes the clinical significance of antibiotic resistance, the mechanisms of resistance, and suggests strategies to combat resistance. Summary: Antibiotic re...

conclusions methicillin resistance is a specialized concern in clinical studies, and it is mandatory to detect this mechanism by an accurate method that is updated periodically. increasing the resistance of s. aureus to multiple antibiotics underlines the need for intermittent resistance surveillance. results methicillin resistance was detected in 38% of s. aureus isolates, confirmed by the aga...

Antibiotic selection pressure and genetic associations may lead to the cooccurrence of resistance and virulence in individual pathogens. However, there is a lack of rigorous epidemiological evidence that demonstrates the cooccurrence of resistance and virulence at the population level. Using samples from a population-based case-control study in 25 villages in rural Ecuador, we characterized res...

The increasing usage of antibiotics in the animal farming industry is an emerging worldwide problem contributing to the development of antibiotic resistance. The purpose of this work was to investigate the prevalence and antibiotic resistance profile of bacterial isolates collected from animal farming aquatic environments and meats in a peri-urban community in Daejeon, Korea. In an antibacteria...