multiple sclerosis (ms) is an inflammatory demyelinating and neurodegenerative disorder of  the  central  nervous  system (cns), which mainly affects  young adults. activated t lymphocytes promote the neuro-inflammatory cascade of ms by secreting pro-inflammatory cytokines and play a significant role in its pathogenesis. t  lymphocytes may trigger the inflammation, which in turn leads to axonal...

the multiple sclerosis (ms) is a chronic disease of cns leads to some dysfunctions including cognitive (working memory), mood (depression) and fatigue. in spite of previous investigations about working memory impairment in patients with ms, there are scare evidences for working memory dysfunction in mild disabled ms patients (edss

The Multiple Sclerosis Data Alliance (MSDA), a global multi-stakeholder collaboration, is working to accelerate research insights for innovative care and treatment people with multiple sclerosis (MS) through better use of real-world data (RWD). Despite the increasing reliance on RWD, challenges limitations complicate generation, collection, these data. MSDA aims tackle sociological technical ar...

introduction: multiple sclerosis is a chronic inflammatory disease of central nervous system. the etiology of ms is slightly known, but genetic and environmental factors are reported. vitamin d regulates gene expression and affects target cell functions. the aim of this study was to investigate the expression variation of il-2 and il-4 genes under vitamin d supplementation in patients with mult...

sjogren-larsson syndrome (sls) is an inherited autosomal recessive neurocutaneous disorder with congenital ichthyosis, spastic diplegia or quadriplegia and mental retardation. we report a case of sjogren-larsson syndrome with clinical profile (mental retardation, ichthyosis, spastic diplegia) and mri findings such as seen in multiple sclerosis (ms). so this rare syndrome can be another differen...

Background: Multiple Sclerosis (MS) is one of the most important diseases due to its adverse clinical, social and economic consequences for affected people. This study tried to assess the quality of life of the patients suffering from Multiple Sclerosis in East Azerbaijan. Methods: This cross-sectional study used the Multiple Sclerosis Quality of Life-54 (MSQOL-54) questionnaire for interviewi...

Conduction along the optic nerve is often slowed in multiple sclerosis (MS). This is typically assessed by measuring the latency of the P100 component of the Visual Evoked Potential (VEP) using electroencephalography. The Visual Evoked Spread Spectrum Analysis (VESPA) method, which involves modulating the contrast of a continuous visual stimulus over time, can produce a visually evoked response...

Multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), are chronic inflammatory demyelinating disorders of central nervous system (CNS). While the cause is unclear, the fundamental mechanism is thought to be destruction of myelin sheaths of neurons through immune system. One of the approaches being proposed in EAE therapy is neural stem cells (NSCs) trans...