Treatment for patients with pulmonary nontuberculous mycobacterial (NTM) disease includes long, multi-drug, and toxic medication regimens. Surgical resection is an alternative treatment localized or refractory NTM infection. Robot-assisted operations have not been performed routinely in this population.

Mycobacterium tuberculosis (Mtb) is the most common co-infection in HIV patients and a serious co-epidemic. Apart from increasing the risk of reactivation of latent tuberculosis (TB), HIV infection also permits opportunistic infection of environmental non-pathogenic mycobacteria. To gain insights into mycobacterial survival inside host macrophages and identify mycobacterial proteins or processe...

OBJECTIVE To determine and describe clinical symptoms, demographic characteristics and environmental exposures as determinants of pulmonary mycobacterial diseases among patients examined for tuberculosis in agropastoral communities in Northern Tanzania. METHODS This was a cross sectional study. Sputum samples were collected from patients attending three hospitals in Tanzania, and were investi...

Antibody binding to trehalose mycolates, such as that shown, was evaluated in ELISA. Median responses with the serum of individuals no known mycobacterial infection were low; some very high, majority from Welsh farmers older than 55.

BACKGROUND Bacillus Calmette-Guerin (BCG) vaccine is the most widely administered vaccine in the world, yet its mechanism of action remains unclear. We hypothesize that certain immune pathways are associated with reduced mycobacterial growth following BCG challenge in human volunteers. METHODS We used samples from a mycobacterial challenge in which previously BCG-vaccinated or BCG-naive adult...

Dynamic nanomechanics and nanostructures of dividing and anti-mycobacterial drug treated mycobacterium remain to be fully elucidated. Atomic force microscopy (AFM) is a promising nanotechnology tool for characterization of these dynamic alterations, especially at the single cell level. In this work, single dividing mycobacterium JLS (M.JLS) before and after anti-mycobacterial drug (ethambutol, ...

A 13 year old female patient had multiple hospital visits since age of 6months. The most striking diagnosis was repeated mycobacterial infections; which were diagnosed at times clinically and other with bacteriological confirmation. She tuberculosis affecting lymph nodes, skin soft tissue, bone joints, lungs epidural para-spinal regions. has been treated 4 first line, ones second line anti-Tb d...