Abstract A dataset of (E)-N’-benzylideneisonicotinohydrazide derivatives as a potent anti-mycobacterium tuberculosis has been investigated utilizing Quantitative Structure-Activity Relationship (QSAR) techniques. Genetic Function Algorithm (GFA) and Multiple Linear Regression Analysis (MLRA) were used to select the descriptors and to generate the correlation QSAR models that relate the Mi...

Tuberculosis (TB) is a deadly disease caused by the Mycobacterium tuberculosis bacteria which affects lungs. has become public health problem in Indonesia and around world. prevention one of goals Sustainable Health Development (SDGs). In year 2020, 17.3% TB patients were 45-54 years old, 16.8% 25-34 16.7% 15-24 old. The treatment coverage (TC) cases 2020 was 41.7%, lower than three ago. medica...

Background and Aims: Unlike many global efforts to eradicate tuberculosis caused by Mycobacterium, it remains as a life-threatening infection with a worldwide incidence of 1.5 million cases each year. However, due to the lack of information about Mycobacterium tuberculosis characterization, more studies are required to evaluate strain diversity and epidemiology of tuberculosis to improve the th...

abstractmammary tissue, skeletal muscle, and spleen are less frequently affected by mycobacterium tuberculosis (tb).the most common age for breast tb is between 50 and 70. on this article, we are reporting a 72-year-old womanwho presented with chronic cough, lobar consolidation in right middle lobe (rml) on the cxr, and a massin her right breast revealed on the physical examination. biopsy from...

conclusions results of the current study showed the high prevalence of m. tuberculosis among the patients with lung cancer; therefore, it seems that continuous surveillance is essential to monitor the m. tuberculosis in the patients with lung cancer. results the subjects included 252 (66.3%) males and 128 (33.7%) females. based on cultural and microscopic methods, m. tuberculosis infection was ...

discussion transthoracic echocardiography disclosed massive pericardial effusion, respiratory variation in mitral and tricuspid inflow e velocity, increased diastolic flow reversal with expiration in the hepatic vein, septum deviation in inspiration toward the left ventricle (lv), preserved lv function, and inferior vena caval (ivc) dilation without any collapse in inspiration. chest computed t...

background: tuberculosis (tb) remains as a major cause of death around the world. construction of a new vaccine against tuberculosis is an effective way to control it. several vaccines against this disease have been developed. the aim of the present study was to cloning of tb10.4 gene in pcdna3.1+ plasmid and evaluation of its expression in eukaryotic cells. methods: firstly, tb10.4 fragment wa...

a modified pulsed-field gel electrophoresis (pfge) protocol was developed and applied to clinical isolates of mycobacterium tuberculosis complex to reduce the cost of using lyticase. this protocol reduces the expense of pfge typing of mycobacterium tuberculosis complex as it removes the use of lyticase during the spheroplast formation from these bacteria.