The aim of this work was to develop a new in vitro lipolysis-permeation model predict the vivo absorption fenofibrate self-nanoemulsifying drug delivery systems (SNEDDSs). More specifically, intestinal lipolysis combined with mucus-PVPA (Phospholipid Vesicle-based Permeation Assay) permeability model. Biosimilar mucus (BM) added surface PVPA barriers closer simulate mucosa. SNEDDSs for which ph...

Paliperidone is a BCS-II drug. It means paliperidone poorly water soluble and hence shows problem in absorption as well permeation through GIT which together contributes for its lower oral bioavailability. drug, oil oleic acid, surfactant labrasol co labrafil m 1944 were taken formulation done. From the emulsification time study concentration of Smix increases decreases. Further I found that F3...

Piroxicam belongs to BCS class II and has low solubility. Self-nanoemulsifying drug delivery systems (SNEDDS) are considered a potential approach for increasing the solubility release of piroxicam. This study aimed select components component ratios piroxicam SNEDDS using fractional factorial design 26-2 (FFD). The variables used in DFT development type concentration oil (triacetin oleic acid),...

the objective of present research was to design, evaluate and compare drug release from two different dosage forms in pulsatile drug delivery system (dds) for metoprolol tartarate (mt) as tablet and capsule. pulsatile systems are gaining a lot of interest as they deliver the drug at the right site of action at the right time and in the right amount, thus providing spatial and temporal delivery ...

Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate ves...