Javad Akhtari
Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
[ 1 ] - DDA/TDB liposomes containing soluble Leishmania major antigens induced a mixed Th1/Th2 immune response in BALB/c mice
Objective(s): Leishmaniasis is a complex parasitic disease that represents a major public health problem. Despite numerous attempts over the past decades, yet there is no effective vaccine against human leishmaniasis probably due to the lack of suitable adjuvants. In this study, a first generation liposomal-based Leishmania vaccine was developed using soluble Leishmania major antigens (SLA) and...
[ 2 ] - سلول های بنیادی سرطانی: ناهمگونی در سلول‌های سرطانی و راهکارهای نانوتکنولوژی در درمان آن‌ها
Cancer stem cells are believed to be responsible for the cancer-initiating step and resistance to chemotherapy drugs. Studies have shown that cancer stem cells are silent and have no metabolic activity. The main reasons behind tumors resistant to therapies are lack of activity of cancer stem cells and division of cancer cells. This cell population, like normal stem cells, is capable of self-ren...
[ 3 ] - In vitro antitumor activity of patulin on cervical and colorectal cancer cell lines
Background and Purpose: Patulin is a mycotoxin produced by some molds,especially Aspergillus and Penicilium, and is responsible for mycotoxicosis in animals and humans.There is still not very detailed data about the anti-cancer potency of patulin, but some reports demonstrated that it induces cellular apoptosis and toxicity. Materials and Methods: To determine the efficacy of patulin as a ther...
[ 4 ] - Vaccine design based on Live attenuated cells of Toxoplasma gondii: a review
Toxoplasma gondii is well- known as a common parasite with high proliferative activity in the nucleated cells. This parasite has infected nearly one third of the people worldwide. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and abortion and neonatal loss in congenital toxoplasmosis. Development of vaccines for toxoplasmosis infect...
[ 5 ] - Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in Iranian Patients
Background: We aimed here to investigate the association between alleles and genotypes of APOE and Age-related macular degeneration (AMD) development. Materials and Methods: After ophthalmological examination, 120 patients with confirmed AMD and 120 healthy controls were enrolled in the study. The polymorphic segment of APOE gene was PCR-amplified and sequenced to determine the frequency distr...
[ 6 ] - کاربرد نانوذرات در فرمولاسیون اسانس ها
زمینه و هدف: نانوتکنولوژی توانایی کنترل ویژگی های مواد در مقیاس اتمی و مولکولی است. حوزه پزشکی مدرن و داروسازی هم تحت تأثیر این فناوری قرار گرفته است. در این زمینه بیشترین تمرکز تحقیقاتی بر درون گیری ترکیبات فعال دارویی مخصوصاً داروهای سایتوتوکسیک بوده است. اسانس ها ترکیباتی هستند که کاربردهای درمانی و بهداشتی و آرایشی دارند. آن ها مخلوط پیچیده ای از انواع مولکول های فرار آروماتیک و آلیفاتیک هس...
[ 7 ] - Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review
Skin is an important organ of the body due to offering an accessible and convenient site for drug administration. One of the disadvantages of transdermal drug delivery is the low penetration rate of drugs through the skin. Over the past decades, nanoparticles have been used as drug delivery systems to increase therapeutic effects or reduce toxicity. Encapsulation of drugs in nanoparticulate ves...
[ 8 ] - Immunogenicity and protection effects of cationic liposome containing imiquimod adjuvant on leishmaniasis in BALB/c mice
Objective(s): Protection against leishmaniasis, in the murine model, is dependent on developing a potent CD4+ mediated Th1 type response. Liposomes can be applied as immunoadjuvants to stimulate immune responses to different antigens. In the present study, it was investigated whether DOTAP liposomes having SLA and imiquimod adjuvant, can induce a Th1 response and prote...
[ 9 ] - Injectable Hydrogels: A Review of Injectability Mechanisms and Biomedical Applications
Hydrogels have been used for biomedical applications in recent decades. They are a perfect candidate for regenerative medicine as they resemble the extracellular matrix of native tissues. In addition, their highly hydrated structure makes them a suitable choice for drug and other therapeutics delivery. Injectable hydrogels have increasingly gained attention due to their capability for homogeneo...
[ 10 ] - Liposomes containing the imiquimod adjuvant as a vaccine in the cutaneous leishmaniasis model
Objective(s): Attempts to produce vaccines for leishmaniasis need adjuvants to trigger the kind of immune reaction required for protection. In this study, we examined the properties of the TLR7 agonist imiquimod, a vaccine adjuvant, making use of a live model of infection where the immune reactions could be identified prior to and following the challenge of infection. Materials and Method...
[ 11 ] - Kinetoplast DNA: A Promising Drug Target for Treatment of Leishmaniasis
Leishmaniasis is a vector-borne zoonotic disease caused by various species of the genus Leishmania, (trypanosomatidae family) that is transmitted by phlebotomine sandflies. The disease can present in a range of clinical forms, including dermal lesions, metastasis mucocutaneous forms, and fatal visceral forms. In this non-systematic review, we aimed at introducing the role of kinetoplast DNA (kD...
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