Abdolrazagh Marzban
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
[ 1 ] - Annual Antibiotic Related Economic Burden of Healthcare Associated Infections; a Cross-Sectional Population Based Study
Abstract: So far, too little attention has been paid to total burden of healthcare associated infections (HAIs) in Iran. In present study, we aimed to assess the rate of HAIs, as well as economic burden of hospitalization and antibiotic related cost associated with HAIs at training Taleghani hospital in Iran and to compare our results with NNIS system. This research to date for the first time h...
[ 2 ] - Annual Antibiotic Related Economic Burden of Healthcare Associated Infections; a Cross-Sectional Population Based Study
Abstract: So far, too little attention has been paid to total burden of healthcare associated infections (HAIs) in Iran. In present study, we aimed to assess the rate of HAIs, as well as economic burden of hospitalization and antibiotic related cost associated with HAIs at training Taleghani hospital in Iran and to compare our results with NNIS system. This research to date for the first time h...
[ 3 ] - تولید آنزیم ضد لوسمی ال-آسپاراژیناز توسط سویه ای از استافیلوکوکوس جداسازی شده از خاک کشاورزی
Background and purpose: L-asparaginase is a well-known enzyme that is used as one of the most effective anti-leukemic drugs. Considering that the asparaginases used as antitumor are bacterial-based enzymes, the aim of this study was to find indigenous potential bacteria producing asparaginase. Materials and methods: The enzyme producing bacteria was isolated from the agricultural soils aroun...
[ 4 ] - Vaccine design based on Live attenuated cells of Toxoplasma gondii: a review
Toxoplasma gondii is well- known as a common parasite with high proliferative activity in the nucleated cells. This parasite has infected nearly one third of the people worldwide. Infection can result in chorioretinitis in immunocompetent hosts, encephalitis in HIV/AIDS positive patients and abortion and neonatal loss in congenital toxoplasmosis. Development of vaccines for toxoplasmosis infect...
[ 5 ] - Genetic Variations in Host Factors and their Critical Role on HCV Medication
Although standard treatments are nearly life-saving in hepatitis C patients, all patients equalldon’t respond to such medications. To achieve an efficient therapeutic response in all patients, medications should individually alter based on genetic factor variations. Hence, having more detailed knowledge of the affective factors on the disease promotion could help us to organize an appropr...
[ 6 ] - آنالیز نواحی تکراری چند ناحیه ای (MLVA) به منظور تیپ بندی سویه های سودوموناس آئروژینوزای عامل عفونت ادراری
سابقه و هدف: سودوموناس آئروژینوزا یکی از شایع ترین عوامل عفونتهای ادراری در بیمارستانها می باشد. هدف از این مطالعه تعیین تیپ تعدادی از جدایه های بدست آمده از بیماران به روش MLVA به منظور رسیدن به یک الگوی ژنتیکی مشخص برای دسته بندی آنها میباشد. مواد و روش ها: در این مطالعه 70 سویه سودموناس آئروژینوزا از نمونه ادراری بیماران در بیمارستان های تهران جمع آوری شد. برای بررسی ژنوتیپی بر اساس روش ...
[ 7 ] - L-Asparaginase-producing Rouxiella Species Isolation, Antileukemia Activity Evaluation, and Enzyme Production Optimization
Background: L-Asparaginase (L-Asp) is used as an efficient anti-cancer drug, especially for acute lymphoblastic leukemia (ALL). Currently, two bacterial asparaginase isoenzymes are used for cancer treatment. Therefore, this research focused on isolating native bacteria with the ability to produce L-Asp. Materials and methods: L-Asp producing bacteria were isolated from soil samples on 9K medi...
[ 8 ] - Surveying the Antioxidant and the Antimicrobial Effects of Aqueous and Ethanolic Extract of Rumex Alveollatus L. on In-vitro Indicator Microorganisms
Background & Objective: In recent years, more attention has been devoted to herbal medicines. Up to now, many compounds with therapeutic effects has been extracted from the herbs. The aim of this study is to evaluate the antioxidant and the antimicrobial effect of Rumex Alveollatus L. and to partially identify the effective compounds in this plant. Materials & Methods: Extraction was perf...
[ 9 ] - Inhibitory and Stimulatory Effects of Some Metals on Asparaginase Activity Produced by Staphylococcus MGM1
Background: Asparaginases are known to be the cornerstone for the treatment of acute lymphoblastic leukemia (ALL) and are used for treatment in all pediatric regimens as well as in the majority of adult treatment protocols. Clinical hypersensitivity reactions against commercially available asparaginase have resulted in the failure in the treatment of ALL in more than 60% of cases. Thus, it is...
[ 10 ] - Isolation and Characterization of Lytic Bacteriophages from Wastewater against Listeria monocytogenes
Background and Aims: In the current study, two bacteriophages were isolated from the wastewater sources and characterized by lytic activity against the Listeria monocytogenes (L. monocytogenes) bacterium. Materials and Methods: 50 wastewater samples were collected from the disposal sites. The phages were isolated from the treated samples using the double agar overlay method with L. monocytoge...
[ 11 ] - Is the Alternative Healthy Eating Index (AHEI) Associated with Depression and Anxiety?
Anxiety and depression are among the mental disorders that are highly prevalent in advanced and developing societies. Statistics show that one in five people, especially women, suffer from these disorders at some point in their lives. In Iran, the prevalence of anxiety is 15.6% and depression is 12.7% (Khademian et al., 2021, Mohammadi et al., 2019)
[ 12 ] - The Role of Foods and Beverages in the Effectiveness of Drugs
Foods and nutrients in them are one of the most important and variable factors affecting the bioavailability and function of oral drugs in the body. Foods affect the effectiveness of drugs in different ways. Just as medications often reduce the absorption of nutrients, foods often reduce the effectiveness of medications; food in the stomach delays the absorption of penicillin and amoxicillin an...
[ 13 ] - Anti-Mycobacterium Tuberculosis Effects of Folk Medicinal Plants in Iran: A Mini-Systematic Review
The emergence of drug resistance in Mycobacterium tuberculosis is a major challenge in tuberculosis treatment and control. In addition, multidrug resistance (MDR) and, more broadly, extensive drug resistance (XDR) have hampered treatment with common antibiotics. Thus, an herbal medicine containing antimicrobial capability can be a good alternative to antituberculosis drugs. In this study, we re...
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