For more than two decades, there has been continuing evidence of lipid oxidation playing a central role in atherogenesis. The oxidation hypothesis of atherogenesis has evolved to focus on specific pro-inflammatory oxidized phospholipids, which result from the oxidation of LDL phospholipids containing arachidonic acid, and which are recognized by the innate immune system in animals and humans. T...

THE International Symposium on Mixed and Augmented Reality (ISMAR) is pleased to again this year present a special section of the best papers from the annual conference. Mixed and augmented reality continue to show dramatic improvements in capabilities and the reach of applications; this year’s award winning papers demonstrate this progress quite well. The ISMAR submission process continues to ...

Journal of Lipid Research Volume 53, 2012 437 Copyright © 2012 by the American Society for Biochemistry and Molecular Biology, Inc. Apolipoprotein A-I (apoA-I) mimetic peptides have been studied in animals and humans for their ability to improve biomarkers of infl ammation and in animal models of atherosclerosis for their ability to decrease lesions ( 1 ). The mechanism of action of these pepti...

Emerging evidence suggests that HDL function is not always accurately predicted by HDL cholesterol levels. The functions of HDL include reverse cholesterol transport and modulation of inflammation. These functions appear to have evolved as part of the innate immune system. In healthy individuals, in the absence of systemic oxidative stress and inflammation, HDL is anti-inflammatory. However, in...

Ou et al 1 report that an apolipoprotein A-I (apoA-I) mimetic peptide, D-4F, reduced wall thickness and improved vasoreactivity in the fascialis artery (internal diameter 180 to 240 m) in low-density lipoprotein (LDL) receptor–null mice on a Western diet. If the mice also lacked apoA-I, D-4F improved vasoreactivity but it did not reduce wall thickness. The authors concluded that apoA-I or some ...

Voltage-gated sodium (NaV) channels, initially characterized in excitable cells, have been shown to be aberrantly expressed non-excitable cancer tissues and cells from epithelial origins such as breast, lung, prostate, colon, cervix, whereas they are not cognate non-cancer tissues. Their activity was demonstrated promote aggressive invasive potencies of both vitro vivo, their deregulated expres...

BackgroundAdequate deltoid and rotator cuff elongation in reverse shoulder arthroplasty is crucial to maximize postoperative functional outcomes avoid complications. Measurements of during preoperative planning can support surgeons selecting a suitable implant design position. Therefore, this study presented evaluated fully automated method for measuring elongation.MethodsComplete scapular hume...

•Enhancement attacks falsely improve the performance of connectome-based models•Adversarial degrade models•Subtle data manipulations lead to large changes in In recent years, machine learning models using brain functional connectivity have furthered our knowledge brain-behavior relationships. The trustworthiness these has not yet been explored, and determining extent which can be manipulated ch...

Despite​ ​advances​ ​in​ ​artificial​ ​intelligence​ ​(AI),​ ​its​ ​application​ ​in​ ​medical​ ​imaging​ ​has​ ​been burdened​ ​and​ ​limited​ ​by​ ​expert-generated​ ​labels.​ ​We​ ​used​ ​images​ ​from​ ​optical​ ​coherence tomography​ ​angiography​ ​(OCTA),​ ​a​ ​relatively​ ​new​ ​imaging​ ​modality​ ​that​ ​measures​ ​retinal​ ​blood flow,​ ​to​ ​train​ ​an​ ​AI​ ​algorithm​ ​to​ ​generat...