نتایج جستجو برای: negative breast cancer
تعداد نتایج: 1460192 فیلتر نتایج به سال:
Background &Objective;: Breast cancer is the most common female malignancy. Detection of DNA of human papillomaviruses (HPVs) in breast carcinomas suggests that the virus may play a role in the pathogenesis of this disease. The aim of this study was to evaluate the frequency of HPVs genotypes 6, 11, 16, 18 and 31 in paraffin-embedded tissue samples of invasive breast carcinomas. Me...
BACKGROUND The association between family history and risk of triple negative breast cancer and ductal carcinoma in situ (DCIS) has not been well investigated, especially in Asian populations. We investigated the association between family history and risk of DCIS or triple negative breast cancer in a Han Chinese population. METHODS A case-control study, comprising 926 breast cancer patients ...
Triple-negative breast cancer is a high-risk breast cancer with poor survival rate. To date, there is a lack of targeted therapy for this type of cancer. One unique phenomenon is that inflammatory breast cancer is frequently triple negative. However, it is still ambiguous how inflammation influences triple-negative breast cancer growth and responding to chemotherapy. Herein, we investigated the...
چکیده مقدمه: سرطان پستان امروزه با شیوع روز افزونی جزء معضلات سلامت بویژه در جوامع صنعتی بشمار می آید. علیرغم مطالعات گسترده انجام شده هنوز هم اطلاعات دقیق و ضروری در خصوص ارتباط بین ریسک فاکتور های این سرطان با بسیاری از پیامدهای آن در دسترس نیست. این مطالعه با توجه به شیوع بالای سرطان پستان در ایران و بویژه در شهر یزد و با هدف تعیین ارتباط میزان بقا و عود با الگوی عوامل خطر در بیماران مبتلا...
background: it has been previously demonstrated that her-2 (human epidermal growth factor receptor 2) positive breast cancers are associated with an aggressive nature. villin is an actin bundling protein that plays a key role in actin reorganization and cell remodeling during stress. in this study, we aimed to investigate the correlation of villin gene expression with her-2 in breast cancer pat...
Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and ...
Triple-negative breast cancer has recently been recognized as an important subgroup of breast cancer with a distinct outcome and therapeutic approach when compared with other subgroups of breast cancer. Triple-negative breast cancer comprises primarily, but not exclusively, a molecularly distinct subtype of breast cancer, the basal-like subtype. We do not yet have an assay to identify basal-lik...
Genome-wide association studies (GWAS) of breast cancer defined by hormone receptor status have revealed loci contributing to susceptibility of estrogen receptor (ER)-negative subtypes. To identify additional genetic variants for ER-negative breast cancer, we conducted the largest meta-analysis of ER-negative disease to date, comprising 4754 ER-negative cases and 31 663 controls from three GWAS...
background: inflammatory breast cancer (ibc), a subgroup of locally advanced breast cancer (labc), is diagnosed based on clinical findings, and seems to be different from other types of labc. the purpose of this study was to compare clinicopathological characteristics and outcomes between inflammatory and non-inflammatory labc patients at breast cancer research center (bcrc), tehran, iran. meth...
Background and purpose: Regional lymph node involvement is one of the main prognostic factors for breast cancer. Intraoperative assessment of sentinel lymph node biopsy (SLNB) by frozen section (FS) allows necessary axillary lymph node dissection (ALND) at the same time. But, false negative results are the main problems of the FS. The aim of this study was to investigate the relationship betwee...
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