OBJECTIVE Infantile Krabbe disease, a rare neurodegenerative disorder that leads to rapid demyelination, dysmyelination, and death in the first 2 years of life, is responsive to treatment with umbilical cord blood transplantation provided that the patient is treated in the first weeks of life. At present, family history is the only way to identify patients that are asymptomatic with most patien...

Schizophrenia, once considered a psychological malady devoid of any organic brain substrate, has been the focus of intense neuroimaging research. Findings reveal mild but generalized tissue loss as well as more selective focal loss. It is unclear whether these abnormalities reflect neurodevelopmental or neurodegenerative processes, or some combination of each; current evidence favors a preponde...

Contents Preface ix Acknowledgments x Contributors xi Chapter 1. The Development in Neurodevelopmental 1 Treatment (NDT) for the SLP Fran Redstone How a child's motor milestones relate to achievement of functional oral–motor and cognitive/linguistic skills.

BACKGROUND Several clinical and radiological markers of early neurodevelopmental deviations have been independently associated with cognitive impairment in patients with schizophrenia. The aim of our study was to test the cumulative and/or interactive effects of these early neurodevelopmental factors on cognitive control (CC) deficit, a core feature of schizophrenia. METHODS We recruited pati...

OBJECTIVES Neonates with hypoplastic left heart syndrome (HLHS) are at risk of high mortality and neurodevelopmental morbidity. As an alternative to Norwood-type stage I palliation, the hybrid procedure has been developed. It consists of bilateral pulmonary artery banding, catheter-based stenting of the arterial duct and balloon atrioseptostomy and delays open-heart surgery. Thus, it may be ass...

Overview: In neurodevelopmental disorders, such as autism spectrum disorder (ASD), intellectual disability (ID) or Attention Deficit Hyperactivity Disorder (ADHD), the tremendous heterogeneity in etiology and clinical presentation can undermine our ability to effectively stratify patients, target interventions, and predict outcomes from those interventions. Research to improve stratification an...

Candidal meningitis is a serious complication of systemic candidiasis and cause of major morbidity and mortality. This is especially true in very low birth weight premature infants. We describe a premature neonate who suffered from systemic candidal infection with brain parenchymal involvement detected by cranial ultrasound. This patient survived after antifungal treatment but delayed neurodeve...

This article reviews the models and theories of motor behavior that are the foundation for the traditional approaches to central nervous system (CNS) dysfunction and presents a new theoretical model and approach that are beginning to influence practice. Reflex, hierarchical, and systems models of motor control and developmental and motor learning theories are discussed. The relationships of the...

Posthemorrhagic hydrocephalus (PHH) is a rare but serious outcome among premature babies in the NICU, with consequences including mortality and severe neurodevelopmental disabilities. The causes of PHH are still not entirely understood, and its prevention and treatment are controversial. Various cerebrospinal fluid biomarkers have been studied in infants with PHH in order to recognize the cause...