Objective(s): Type 1 diabetes (T1D) is an autoimmune disease resulting from inflammatory destruction of islets β-cells. Nowadays, progress in cell therapy, especially mesenchymal stem cells (MSCs) proposes numerous potential remedies for T1D. We aimed to investigate the combination therapeutic effect of these cells with insulin and metformin on neuropeptide Y, melanoco...

We used in situ hybridization techniques to study the distribution of neurones synthesizing somatostatin mRNA and neuropeptide Y mRNA in the hilar region of the hippocampal formation of patients with temporal lobe epilepsy. In the dentate gyrus, somatostatin mRNA- and neuropeptide Y mRNA-synthesizing neurones were found to be exclusively located within the hilar region. Unlike animal models, no...

We have used immunocytochemistry to quantitate neuronai neuropeptide Y in superior cervical ganglia of a strain of nonnotensive Wistar-Otago rats and a related genetically hypertensive strain over the age range 1-60 weeks. The numbers of neuropeptide Y-immunoreactive cells and total ganglionic cell numbers were both greater in ganglia of young nonnotensive than in those of hypertensive rats. Be...

In mammals, somatostatin and neuropeptide Y (NPY) are largely found in the same neurons of the telencephalon. To determine if this is a phylogenetically ancient feature of telencephalic organization, the brain of red-eared turtles was examined using immunofluorescence double-labeling procedures. The results showed that somatostatin and NPY are found almost exclusively in the same neurons in the...

The aim of this paper is to review the present knowledge of interactions between the neuropeptide Y (NPY) system and the hypothalamic-pituitary-adrenal (HPA) axis. On the basis of in vitro and in vivo studies of various animal species, we review the effects of NPY on all levels of HPA axis activity. We also describe the effects of glucocorticosteroids on the NPY system in the hypothalamus, incl...

Variation in the acute response to ethanol between individuals has a significant impact on determining susceptibility to alcoholism. The degree to which genetics contributes to this variation is of great interest. Here we show that allelic variation that alters the functional level of NPR-1, a neuropeptide Y (NPY) receptor-like protein, can account for natural variation in the acute response to...

A39 Long-term depression-like effect of a single immune challenge in neuropeptide Y Y2 and Y4 receptor knockout mice Evelin Painsipp, Herbert Herzog, Günther Sperk and Peter Holzer Research Unit of Translational Neurogastroenterology, Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria Neurobiology Research Program, Garvan Institute of Medical Res...