background: lithium has been the treatment of choice for bipolar disorder (bd) for many years. although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. objective: the aim was to investigate the possible involvement of nitric oxide (no) in modulatory effect of lithium on penile erection (pe). we fur...

objective(s): analgesic effects of oxytocin and it's the other physiological effects were well-known. the aim of present study was determination of nitric oxide role on analgesic effects of oxytocin in mice. materials and methods: 216 male albino mice were divided randomly into two experimental groups, tail flick and formalin test. each experimental group consists of three main groups incl...

We have investigated the kinetics of NO escape from Geobacillus stearothermophilus nitric oxide synthase (gsNOS). Previous work indicated that NO release was gated at position 223 in mammalian enzymes; our kinetics experiments include mutants at that position along with measurements on the wild type enzyme. Employing stopped-flow UV-vis methods, reactions were triggered by mixing a reduced enzy...

Immunosuppressants FK506 and cyclosporin A inhibit neurotoxicity of N-methyl-D-aspartate in primary cortical cultures, while having no effect on quisqualate- and kainate-mediated neurotoxicity. Rapamycin completely reverses the neuroprotective effect of FK506. Both FK506 and cyclosporin A inhibit NMDA-elicited/nitric oxide-mediated increases in cGMP levels in cortical cultures. FK506 has no eff...

Nitric oxide (NO) is one of the critical components of the vasculature, regulating key signaling pathways in health. In macrovessels, NO functions to suppress cell inflammation as well as adhesion. In this way, it inhibits thrombosis and promotes blood flow. It also functions to limit vessel constriction and vessel wall remodeling. In microvessels and particularly capillaries, NO, along with gr...

Nitric oxide (NO) has been implicated in large number of pathologies ad in normal physiological function of the brain. The aim of this study was to recognize the effect of Nitro-L-Arginine Methyl Ester mHC1 (NAME) and L-Arginine Ethyl Ester.HC1 (ARGININE) on reactivity of the central DA Dg receptor to agonist (Quinpirole) in rats. For this reason we have been used specific behavioural procedure...

endo-derived nitric oxide (no) is synthesized from l-arginine by endothelium nitric oxide synthase (enos). since reduced no synthesis has been implicated in the development of coronary atherosclerosis; we hypothesized that polymorphisms of nos gene might be associated with increased susceptibility to this disorder and coronary artery disease (cad). we studied the 27 base pair tandem repeat poly...