PURPOSE Signaling through the fibroblast growth factor (FGF) pathway may account for tumor resistance to antiangiogenic therapies targeting the VEGF pathway. Here, dovitinib (TKI258), a potent oral inhibitor of FGF receptor, VEGF receptor (VEGFR), and platelet-derived growth factor receptor tyrosine kinases, is studied in a dose escalation trial. EXPERIMENTAL DESIGN Patients with advanced or ...

Estrogen receptor (ER) positive rates in breast cancer may be influenced by grade, stage, age and race. This study reviews the ER positive rates over a 15-year period at the University Malaya Medical Centre, Kuala Lumpur, Malaysia. Data on ER status of 3557 patients from 1994 to 2008 was analyzed. ER status was determined by immunohistochemistry with a cut-off point of 10%. ER positivity increa...

one studies the $hx$-hypergroups, corresponding to the chinese hypergroups associated with the direct products of some ${bf z}/n {bf z},$ calculating their fuzzy grades.

in this study we have described our varicocele cases in terms of associated symptoms/signs. in addition, we have tested the correlation between semen parameters and varicocele grades and compared the relative frequencies of associated symptoms/signs in different varicocele grades. 1 19 referred cases of varicocele were categorized based on clinical criteria into 3 grades by one examiner. the re...

In this paper, we introduce and analyze a new cut-off priority scheme which provides a better grade-of-service to handoff traffic while maintaining high throughput for the originating calls. A hysteresis control is used for additional robustness. The system model is found to have a general level dependent Quasi-Birthand-Death (QBD) structure. An efficient solution methodology is used taking ful...

To ascertain the usefulness of a 21-item checklist that assesses accumulated fatigue due to overwork, we examined (1) the associations between overtime work, job stressors, or the quantity of sleep/rest and subjective symptoms of fatigue, and (2) whether sleeping hours and monthly days off are associated with the accumulated fatigue parameter using the checklist. Questionnaire surveys were admi...

Regorafenib is an oral multi-kinase inhibitor used as salvage therapy for metastatic colorectal cancer (mCRC). We tested whether serum cytokine levels are associated with clinical outcome in the mCRC patients receiving regorafenib. Serum samples were collected before treatment start, day 21, and progressive disease, and eleven angiogenic and inflammatory cytokine serum levels were examined. Fif...

OBJECTIVES The objective of this study was to analyse the relationship between the intraoperative transit-time flow measurement (TTFM) parameter values and the postoperative angiographic results of gastroepiploic arterial (GEA) grafts to the right coronary artery (RCA). We investigated whether the intraoperative TTFM parameter values are reliable indicators of early patency in GEA grafts to the...

BACKGROUND We aimed to determine whether synovial fluid (SF) biomarkers can predict the progression of articular cartilage damage as determined by arthroscopic evaluation during and after anterior cruciate ligament (ACL) reconstruction. METHODS Arthroscopic assessment of articular cartilage damage was performed twice in 62 patients, first during ACL reconstruction and then approximately 2 yea...