Background: Repeated administration of amphetamine elicits a progressive enhancement in behavioral and subjective responses to the drug and an increase in amphetamine-induced dopamine release. This enhancement is called sensitization and is able to induce changes in the response of the brain dopamine system to amphetamines mimicking certain aspects of dopaminergic dysfunction in schizophrenia. ...

AIM This study aimed to compare 6-month adherence to therapy with exenatide once weekly (Bydureon(®)) vs liraglutide once daily (Victoza(®)) in patients with type 2 diabetes under primary care in Germany. METHODS A nationwide longitudinal prescription database (LRx), (between January 2011 and September 2014) was used to analyze adherence to therapy. The proportion of days covered (PDC) by pre...

Oral naltrexone, a nonselective opioid antagonist, is approved for the treatment of alcohol and opioid dependence. However, the efficacy of oral naltrexone is limited by poor patient compliance. To overcome this limitation, attempts have been made to develop an injectable extended-release formulation of naltrexone, including encapsulation into biodegradable polymer microspheres (e.g. Medisorb N...

Aims: To describe perceived negative consequences (PNCs) of alcohol consumption related to the frequency of heavy episodic drinking (HED) in a Swedish population attending primary health care (PHC). Methods: Data from a computer-based assessment, including questions about alcohol consumption and PNC, were collected from 28 PHC centres in Sweden. The analysis included 4559 responders. Risk ratio...

Background: Tinea pedis is the most common fungal infection in adults. It is a common problem in communal areas such as swimming pools and hotels. Objective: To determine the frequency of tinea pedis in adult Muslims regularly attending mosques and to compare it with a control group. Patients and Methods: In a case-control study in 4 randomly selected mosques in Kerman, 99 adult Muslims praying...