alpha-Tocopherol succinate (TS), an analogue of vitamin E, has growth-inhibitory activity in a wide spectrum of in vitro and in vivo cancer models. Here, we report that modulation of oncogenic Ras is associated with TS activity. TS inhibits the proliferation and induces apoptosis of NIH3T3 cells stably transfected with oncogenic K-Ras and H-Ras, but not NIH3T3 cells expressing empty vector. TS ...

Carcinogenesis is a multistep process and multifactorial disease. It is estimated that in developing countries upto 25% of tumours are associated with various microbes. Microbial carcinogenesis is a major public health problem. Viruses are now accepted as bonafide aetiologic factors of human cancer. A formidable level of evidence has determined that there exists a relationship between certain b...

background and aims: ovarian cancer is one of most common causes of cancer related women's mortalities. human papilloma virus is a known factor concerning cervical cancer but its role in causing ovarian cancer is not yet verified. a few studies also identified hpv dna in ovarian carcinoma tissues. however, some studies did not detect hpv dna in ovarian carcinoma tissues. in this article, we inv...

Oncogenic proteins cooperate to promote tumor development and progression by sustaining cell proliferation, survival and invasiveness. Constitutive epidermal growth factor receptor (EGFR) and nuclear factor κb (NF-κB) activities are seen in multiple solid tumors and combine to provide oncogenic signals to cancer cells. Understanding how these oncogenic pathways are connected is crucial, given t...

Circular RNAs (circRNAs) are a class of endogenous noncoding RNA, which were previously considered as byproduct RNA splicing error. Numerous studies have demonstrated the altered expression circRNAs in organ tissues during pathological conditions and their involvements disease pathogenesis progression, including cancers. In colorectal cancer (CRC), multiple been identified characterized “oncoge...

Normal tissues progressively acquire mutations. Some mutations are positively selected, driving clonal expansions that may colonize the majority of a tissue by old age. In several cases mutant expansion is due to biasing stem cell fate toward proliferation. However, expansionary phase transient and followed reversion wild-type behavior so normal integrity retained. Here we consider implications...

We have recently shown that approximately half of primary multiple myeloma (MM) samples display constitutive Akt activity, which disposes them for sensitivity to Akt inhibition. The Akt pathway counts among the signaling conduits for oncogenic RAS and activating mutations of K- and N-RAS frequently occur in MM. We therefore analyzed the relation between RAS mutation and Akt dependency in biopsi...

We have recently shown that approximately half of primary multiple myeloma (MM) samples display constitutive Akt activity, which disposes them for sensitivity to Akt inhibition. The Akt pathway counts among the signaling conduits for oncogenic RAS and activating mutations of Kand N-RAS frequently occur in MM. We therefore analyzed the relation between RAS mutation and Akt dependency in biopsies...