We designed a prospective study to describe the clinical impact of the parainfluenza viruse (PIV) types detected in hospitalized children with respiratory tract infections from September 2008 to August 2010 in Spain. PIV infections were a significant proportion of viral respiratory detections (11.8% of cases). PIV types 3 and 4 were most commonly detected. There were clinical differences betwee...

intoduction: the discovery of micrornas (mirnas), an extensive family of small non-protein-coding rnas, provided an exciting era in cancer research and recent findings have prompted us to revise the traditional concept of cancer. deregulated mirnas   expression influences biological events leading to cancer such as proliferation, differentiation, metastasis and apoptosis. the expression of onco...

It is estimated that up to 20% of all types of human cancers worldwide are attributed to viruses. The genome of oncogenic viruses carries genes that have protein products that act as oncoproteins in cell proliferation and transformation. The modulation of cell cycle control mechanisms, cellular regulatory and signaling pathways by oncogenic viruses, plays an important role in viral carcinogenes...

Object: To explore the therapeutic effects and therapeutic mechanisms of Conditional Replication Adenovirus(CRAd) in combination with cisplatin on lung cancer cells. Methods: Using MTS / PMS assay, in vitro cell inhibition assay was performed to detect the cell viability of two lung cancer cell lines, NCI-H292 and NCI-H661. PCR was employed to detect the Coxsackie receptor(CAR) expression of ca...

background: alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. the biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interaction...

background: retroviruses of human t-lymphotropic viruses (htlv-1 and htlv-2) have been demonstrated to be endemic in the north-eastern region of iran. this study aims to determine htlv-1 and htlv-2 prevalence among healthy individuals in neyshabur city during 2010-2014. methods: a total of 8054 blood samples were collected from healthy participants in neyshabur, north-eastern iran. the blood sa...