Base-line intraocular pressure was similar in the rabbit eye ivith a transected optic nerve and the opposite eye subjected to a sham operation. Hyperosmotic oral ethanol, at doses of 1.5 to 2.0 ml. per kilogram, lowered intraoctdar pressure significantly less in eyes with transected optic nerves than in their fellow eyes with intact optic nerves. Smaller doses of ethanol (0.75 ml. per kilogram)...

PURPOSE Microglia normally exist in several layers across the retinal thickness. When retinal ganglion cells undergo apoptosis after lesion to their axons, microglial cells proliferate and promptly clear the debris. We have previously reported on the phagocytic response following optic nerve axotomy. Here, we present how microglial cells of deeper retinal layers are affected by transection of t...

BACKGROUND Retinal ganglion cells (RGCs) die in sight-threatening eye diseases. Imaging RGCs in humans is not currently possible and proof of principle in experimental models is fundamental for future development. Our objective was to quantify RGC density and retinal thickness following optic nerve transection in transgenic mice expressing cyan fluorescent protein (CFP) under control of the Thy...

PURPOSE In the current study, a non-histological approach, namely semi-quantitative RT-PCR, was used to provide information on retinal ganglion cell (RGC) injury and survival after optic nerve transection (ONT). The levels of mRNAs synthesized by RGCs and glial components were initially measured at defined time points after ONT. Subsequently, a comparison was made between the levels of these mR...

the purpose of this study was to investigate magnetic resonance imaging (mri) of the normal feline eyeand optic nerves using t1-weighted and t2-weighted images. a total of 6 healthy female domestic short haircats age 2-2.5 years and weighing 3.2 ± 0.4 kg were selected. magnetic resonance imaging data werecollected using gemsow (philips) at a magnetic field strength of 1.5 t. dorsal, sagittal, a...

Glaucoma is a group of eye diseases characterized by alterations in the contour of the optic nerve head (ONH), with corresponding visual field defects and progressive loss of retinal ganglion cells (RGCs). This progressive RGC death is considered to originate in axonal injury caused by compression of the axon bundles in the ONH. However, the molecular pathomechanisms of axonal injury-induced RG...

background :there is not any data available about the effect of high bar pressure condition on intracranial pressure. in this study, the effect of diving on the optic nerve and sheath diameters as non-invasive markers of intracranial pressure has been investigated.   methods : twenty professional male divers from twenty one volunteers were chosen for this cross-sectional study. only one person ...